The plant mitochondrial proteome and its oxidative stress response

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Jesper Foged Havelund, Danmark
ForlagAarhus University, Faculty of Science and Technology
Antal sider159
ISBN (Trykt)978-87-93176-64-5
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 5 mar. 2015

Note vedr. afhandling

Stress of any kind generally leads to an increased rate of reactive oxygen species (ROS) formation in the cell. ROS can react with and damage cellular components such as proteins. Under stress, ROS-degrading enzymes may be overwhelmed and ROS accumulates leading to increased damage. To prevent this scenario, a yet unknown signal transduction mechanism triggers a programme of gene expression that is aimed at maintenance of homeostasis through antioxidant activity and metabolic adjustments
During his studies, Jesper F. Havelund investigated the hypothesis that oxidized peptides deriving from oxidatively damaged proteins act as specific ROS messengers from mitochondria to the nucleus. He used plant mitochondria as the model organism and mass spectrometry as the main analytical tool to characterize the mitochondrial proteins and thereby identified peptides which are released due to oxidative stress. Moreover he developed a method for the analysis of oxidative damaged proteins leading to the identification of many different damaged products.
Jesper F. Havelund’s results contribute to our understanding of how oxidative stress causes protein damage and how protein degradation products may be used as signaling molecules of oxidative stress.

The PhD degree was completed at Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

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