The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

Jakob Appel Østergaard; Fanny Jansson Sigfrids; Carol Forsblom; Emma H Dahlström; Lena M Thorn; Valma Harjutsalo; Allan Flyvbjerg; Steffen Thiel; Troels Krarup Hansen; Per-Henrik Groop

doi:10.1038/s41598-021-88352-y

The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

Jakob Appel Østergaard, Fanny Jansson Sigfrids, Carol Forsblom, Emma H Dahlström, Lena M Thorn, Valma Harjutsalo, Allan Flyvbjerg, Steffen Thiel, Troels Krarup Hansen, Per-Henrik Groop

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97-1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04-1.22) and 1.05 (0.93-1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05-1.35) and 1.18 (1.02-1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.

Originalsprog	Engelsk
Artikelnummer	8919
Tidsskrift	Scientific Reports
Vol/bind	11
Nummer	1
Sider (fra-til)	8919
Antal sider	9
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-021-88352-y
Status	Udgivet - apr. 2021

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10.1038/s41598-021-88352-yLicens: CC BY

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076270/pdf/41598_2021_Article_88352.pdfLicens: CC BY

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Østergaard, J. A., Jansson Sigfrids, F., Forsblom, C., Dahlström, E. H., Thorn, L. M., Harjutsalo, V., Flyvbjerg, A., Thiel, S., Hansen, T. K., & Groop, P.-H. (2021). The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes. Scientific Reports, 11(1), 8919. Artikel 8919. https://doi.org/10.1038/s41598-021-88352-y

@article{01e0ad95e86a451da73f9ef9cbcaff4e,

title = "The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes",

abstract = "H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97-1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04-1.22) and 1.05 (0.93-1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05-1.35) and 1.18 (1.02-1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.",

author = "{\O}stergaard, {Jakob Appel} and {Jansson Sigfrids}, Fanny and Carol Forsblom and Dahlstr{\"o}m, {Emma H} and Thorn, {Lena M} and Valma Harjutsalo and Allan Flyvbjerg and Steffen Thiel and Hansen, {Troels Krarup} and Per-Henrik Groop",

year = "2021",

month = apr,

doi = "10.1038/s41598-021-88352-y",

language = "English",

volume = "11",

pages = "8919",

journal = "Scientific Reports",

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Østergaard, JA, Jansson Sigfrids, F, Forsblom, C, Dahlström, EH, Thorn, LM, Harjutsalo, V, Flyvbjerg, A, Thiel, S , Hansen, TK & Groop, P-H 2021, 'The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes', Scientific Reports, bind 11, nr. 1, 8919, s. 8919. https://doi.org/10.1038/s41598-021-88352-y

The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes. / Østergaard, Jakob Appel; Jansson Sigfrids, Fanny; Forsblom, Carol et al.
I: Scientific Reports, Bind 11, Nr. 1, 8919, 04.2021, s. 8919.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

AU - Østergaard, Jakob Appel

AU - Jansson Sigfrids, Fanny

AU - Forsblom, Carol

AU - Dahlström, Emma H

AU - Thorn, Lena M

AU - Harjutsalo, Valma

AU - Flyvbjerg, Allan

AU - Thiel, Steffen

AU - Hansen, Troels Krarup

AU - Groop, Per-Henrik

PY - 2021/4

Y1 - 2021/4

N2 - H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97-1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04-1.22) and 1.05 (0.93-1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05-1.35) and 1.18 (1.02-1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.

AB - H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97-1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04-1.22) and 1.05 (0.93-1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05-1.35) and 1.18 (1.02-1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.

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DO - 10.1038/s41598-021-88352-y

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The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

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