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The Nuclear RNA Exosome and Its Cofactors

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The Nuclear RNA Exosome and Its Cofactors. / Schmid, Manfred; Jensen, Torben Heick.

The Biology of mRNA: Structure and Function. red. / M Oeffinger; D Zenklusen. Springer, 2019. s. 113-132 (Advances in Experimental Medicine and Biology, Bind 1203).

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

Harvard

Schmid, M & Jensen, TH 2019, The Nuclear RNA Exosome and Its Cofactors. i M Oeffinger & D Zenklusen (red), The Biology of mRNA: Structure and Function. Springer, Advances in Experimental Medicine and Biology, bind 1203, s. 113-132. https://doi.org/10.1007/978-3-030-31434-7_4

APA

Schmid, M., & Jensen, T. H. (2019). The Nuclear RNA Exosome and Its Cofactors. I M. Oeffinger, & D. Zenklusen (red.), The Biology of mRNA: Structure and Function (s. 113-132). Springer. Advances in Experimental Medicine and Biology Bind 1203 https://doi.org/10.1007/978-3-030-31434-7_4

CBE

Schmid M, Jensen TH. 2019. The Nuclear RNA Exosome and Its Cofactors. Oeffinger M, Zenklusen D, red. I The Biology of mRNA: Structure and Function. Springer. s. 113-132. (Advances in Experimental Medicine and Biology, Bind 1203). https://doi.org/10.1007/978-3-030-31434-7_4

MLA

Schmid, Manfred og Torben Heick Jensen "The Nuclear RNA Exosome and Its Cofactors". og Oeffinger, M Zenklusen, D (red.). The Biology of mRNA: Structure and Function. Springer. (Advances in Experimental Medicine and Biology, Bind 1203). 2019, 113-132. https://doi.org/10.1007/978-3-030-31434-7_4

Vancouver

Schmid M, Jensen TH. The Nuclear RNA Exosome and Its Cofactors. I Oeffinger M, Zenklusen D, red., The Biology of mRNA: Structure and Function. Springer. 2019. s. 113-132. (Advances in Experimental Medicine and Biology, Bind 1203). https://doi.org/10.1007/978-3-030-31434-7_4

Author

Schmid, Manfred ; Jensen, Torben Heick. / The Nuclear RNA Exosome and Its Cofactors. The Biology of mRNA: Structure and Function. red. / M Oeffinger ; D Zenklusen. Springer, 2019. s. 113-132 (Advances in Experimental Medicine and Biology, Bind 1203).

Bibtex

@inbook{48819600b6d040d888334ef0f269e178,
title = "The Nuclear RNA Exosome and Its Cofactors",
abstract = "The RNA exosome is a highly conserved ribonuclease endowed with 3'-5' exonuclease and endonuclease activities. The multisubunit complex resides in both the nucleus and the cytoplasm, with varying compositions and activities between the two compartments. While the cytoplasmic exosome functions mostly in mRNA quality control pathways, the nuclear RNA exosome partakes in the 3'-end processing and complete decay of a wide variety of substrates, including virtually all types of noncoding (nc) RNAs. To handle these diverse tasks, the nuclear exosome engages with dedicated cofactors, some of which serve as activators by stimulating decay through oligoA addition and/or RNA helicase activities or, as adaptors, by recruiting RNA substrates through their RNA-binding capacities. Most nuclear exosome cofactors contain the essential RNA helicase Mtr4 (MTR4 in humans). However, apart from Mtr4, nuclear exosome cofactors have undergone significant evolutionary divergence. Here, we summarize biochemical and functional knowledge about the nuclear exosome and exemplify its cofactor variety by discussing the best understood model organisms-the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and human cells.",
keywords = "RNA exosome, Nuclear RNA decay, Exosome cofactors, Polyadenylation, TRAMP, NEXT, PAXT, CRYPTIC UNSTABLE TRANSCRIPTS, POLYMERASE-II, MESSENGER-RNA, YEAST EXOSOME, TARGETING COMPLEX, CRYSTAL-STRUCTURE, TRAMP COMPLEX, TERMINATION, DEGRADATION, SURVEILLANCE",
author = "Manfred Schmid and Jensen, {Torben Heick}",
year = "2019",
doi = "10.1007/978-3-030-31434-7_4",
language = "English",
isbn = "978-3-030-31433-0",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "113--132",
editor = "M Oeffinger and D Zenklusen",
booktitle = "The Biology of mRNA: Structure and Function",

}

RIS

TY - CHAP

T1 - The Nuclear RNA Exosome and Its Cofactors

AU - Schmid, Manfred

AU - Jensen, Torben Heick

PY - 2019

Y1 - 2019

N2 - The RNA exosome is a highly conserved ribonuclease endowed with 3'-5' exonuclease and endonuclease activities. The multisubunit complex resides in both the nucleus and the cytoplasm, with varying compositions and activities between the two compartments. While the cytoplasmic exosome functions mostly in mRNA quality control pathways, the nuclear RNA exosome partakes in the 3'-end processing and complete decay of a wide variety of substrates, including virtually all types of noncoding (nc) RNAs. To handle these diverse tasks, the nuclear exosome engages with dedicated cofactors, some of which serve as activators by stimulating decay through oligoA addition and/or RNA helicase activities or, as adaptors, by recruiting RNA substrates through their RNA-binding capacities. Most nuclear exosome cofactors contain the essential RNA helicase Mtr4 (MTR4 in humans). However, apart from Mtr4, nuclear exosome cofactors have undergone significant evolutionary divergence. Here, we summarize biochemical and functional knowledge about the nuclear exosome and exemplify its cofactor variety by discussing the best understood model organisms-the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and human cells.

AB - The RNA exosome is a highly conserved ribonuclease endowed with 3'-5' exonuclease and endonuclease activities. The multisubunit complex resides in both the nucleus and the cytoplasm, with varying compositions and activities between the two compartments. While the cytoplasmic exosome functions mostly in mRNA quality control pathways, the nuclear RNA exosome partakes in the 3'-end processing and complete decay of a wide variety of substrates, including virtually all types of noncoding (nc) RNAs. To handle these diverse tasks, the nuclear exosome engages with dedicated cofactors, some of which serve as activators by stimulating decay through oligoA addition and/or RNA helicase activities or, as adaptors, by recruiting RNA substrates through their RNA-binding capacities. Most nuclear exosome cofactors contain the essential RNA helicase Mtr4 (MTR4 in humans). However, apart from Mtr4, nuclear exosome cofactors have undergone significant evolutionary divergence. Here, we summarize biochemical and functional knowledge about the nuclear exosome and exemplify its cofactor variety by discussing the best understood model organisms-the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and human cells.

KW - RNA exosome

KW - Nuclear RNA decay

KW - Exosome cofactors

KW - Polyadenylation

KW - TRAMP

KW - NEXT

KW - PAXT

KW - CRYPTIC UNSTABLE TRANSCRIPTS

KW - POLYMERASE-II

KW - MESSENGER-RNA

KW - YEAST EXOSOME

KW - TARGETING COMPLEX

KW - CRYSTAL-STRUCTURE

KW - TRAMP COMPLEX

KW - TERMINATION

KW - DEGRADATION

KW - SURVEILLANCE

U2 - 10.1007/978-3-030-31434-7_4

DO - 10.1007/978-3-030-31434-7_4

M3 - Book chapter

SN - 978-3-030-31433-0

T3 - Advances in Experimental Medicine and Biology

SP - 113

EP - 132

BT - The Biology of mRNA: Structure and Function

A2 - Oeffinger, M

A2 - Zenklusen, D

PB - Springer

ER -