The migration of drugs-of-abuse from Europe to Denmark – Analysis of pooled anonymous urine from urinals at Roskilde Festival 2016

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  • Lotte Christine Groth Hoegberg, Department of Anaesthesiology, The Danish Poisons Information Center, Copenhagen University Hospital Bispebjerg-Frederiksberg, Danmark
  • Cecilie Christiansen, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Danmark
  • Jesper Soe, Department of Anaesthesiology, Copenhagen University Hospital Hvidovre, Danmark
  • Rasmus Telving
  • Mette Findal Andreasen
  • Dan Staerk, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Danmark
  • Lona Louring Christrup, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Danmark
  • Kenneth Thermann Kongstad, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Danmark
Objective: The spread of new psychoactive substances (NPS) has expanded rapidly the last decade with 570 new substances registered the last 10 years [1]. New substances are developed to meet the demand for new variations in
effect but also to bypass legislation. Due to the complexity of the effects of NPS, traditional treatment guidelines are challenged. Thus, information of the emergence of new arrivals is of great value. Our knowledge on the actual
range of drugs used and NPS available in Denmark is limited as identification is possible only when consumers become patients in the healthcare system or through police seizures [2]. We carried out a cross-sectional study of
collected pooled anonymous urine, sampled from urinals at the biggest music festival during the year, Roskilde Festival, with the aim to detect classic recreational drugs and NPS. The aim of this study was to identify
recreational drugs currently used and predict the emergence of NPS by comparing study data with seizure data from the previous year published by EMCDDA [1].
Methods: In total 44 urine samples were collected from three urinals at Roskilde Festival 2016. Two urinals were placed at music stages with late-night concerts and techno/electronic music, and one urinal was placed at a camp site. Samples were prepared using enzymatic hydrolysis and cationic and anionic solid phase extraction, and analysed using UPLC-HR-TOFMS. Data was processed against an in-house library of 467 target substances, including legal and illegal drugs and metabolites. Results: In total 77 drugs, including metabolites, were qualitatively identified in the 44 urine samples. The recreational drugs identified (n=number of samples) were amphetamine (n=30), cocaine (n=43), MDMA (n=44),
THC-COOH (n=19), and ketamine (n=17).
Conclusion: Several classical recreational drugs were identified in pooled urine samples. While the widespread use of these drugs at the festival was confirmed, the prevalence of NPS was not as comprehensive as expected based on
the EMCDDA report [1] and the Danish report on illegal drugs [2]. The limited use of NPS and the substantial dilution due to the pooled anonymous nature of the sampling scheme make it difficult to detect single intakes. Thus, the methods used did not allow for predicting the emergence of NPS in Denmark.
References: [1] European Monitoring Centre for Drugs and Drug Addiction (2016), European Drug Report 2016: Trends and Developments, Publications Office of the European Union, Luxembourg. [2] The Danish Health Authority. Illegal drugs in Denmark, 2015 [Danish].
OriginalsprogEngelsk
Udgivelsesår16 maj 2017
Antal sider1
StatusUdgivet - 16 maj 2017
Begivenhed37th Congress of the European Association of Poisons Centres and Clinical Toxicologists - Congress Center Basel, Basel, Schweiz
Varighed: 16 maj 201719 maj 2017
http://www.eapcct2017.com/index.php

Konference

Konference37th Congress of the European Association of Poisons Centres and Clinical Toxicologists
LokationCongress Center Basel
LandSchweiz
ByBasel
Periode16/05/201719/05/2017
Internetadresse

    Forskningsområder

  • NPS, Drugs-of-abuse migration, bioanalysis

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