The Leucine transporter from Aquifex aeolicus as a model for the Neurotransmitter Sodium Symporters – insights into function and ligand binding

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandling

  • Adriana Krassimirova Kantcheva, Danmark
In her PhD studies, Adriana K. Kantcheva looked into the structural perspective of a bacterial transporter – the leucine transporter from Aquifex aeolicus (LeuT) – which is a homologue to neurotransmitter sodium symporters (NSS) found in humans, such as the serotonin transporter. Two crystal structures of LeuT elucidated new insights regarding ion and substrate binding to this transporter.
Studying members of the NSS family is important as these proteins are found in the central nervous system of humans at the synaptic cleft and are implicated in serious conditions such as Parkinson’s disease, epilepsy and depression.

The PhD degree was completed at the Centre for Structural Biology, Science and Technology, Aarhus University.
OriginalsprogEngelsk
ForlagAarhus University, Faculty of Science and Technology
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 8 maj 2013

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