The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy

TY - JOUR

T1 - The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy

AU - Sandahl, Thomas Damgaard

AU - Kelsen, Jens

AU - Dige, Anders

AU - Dahlerup, Jens Frederik

AU - Agnholt, Jørgen

AU - Hvas, Christian Lodberg

AU - Thiel, Steffen

N1 - Copyright © 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

PY - 2014/2/2

Y1 - 2014/2/2

N2 - The lectin pathway of the complement system is initiated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or ficolins and subsequent activation of MBL-associated serine proteases (MASPs). Altered ficolin levels may contribute to a dysregulated immune response in Crohn's disease (CD). A complete analysis of the lectin pathway has not been performed in patients with CD. We hypothesised that the lectin pathway proteins exacerbate inflammation in CD.

AB - The lectin pathway of the complement system is initiated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or ficolins and subsequent activation of MBL-associated serine proteases (MASPs). Altered ficolin levels may contribute to a dysregulated immune response in Crohn's disease (CD). A complete analysis of the lectin pathway has not been performed in patients with CD. We hypothesised that the lectin pathway proteins exacerbate inflammation in CD.

U2 - 10.1016/j.crohns.2013.11.007

DO - 10.1016/j.crohns.2013.11.007

M3 - Journal article

C2 - 24291022

SN - 1873-9946

VL - 8

SP - 521

EP - 528

JO - Journal of Crohn's & Colitis

JF - Journal of Crohn's & Colitis

IS - 6

ER -