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The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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  • Akira Goto, Guangzhou Med Univ, Guangzhou Medical University, Sino French Hoffmann Inst, Sch Basic Med Sci
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  • Kiyoshi Okado, Obihiro Univ Agr & Vet Med, Obihiro University of Agriculture & Veterinary Medicine, Natl Res Ctr Protozoan Dis
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  • Nelson Martins, Guangzhou Med Univ, Guangzhou Medical University, Sino French Hoffmann Inst, Sch Basic Med Sci
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  • Hua Cai, Guangzhou Med Univ, Guangzhou Medical University, Sino French Hoffmann Inst, Sch Basic Med Sci
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  • Vincent Barbier, Univ Strasbourg, Universites de Strasbourg Etablissements Associes, Centre National de la Recherche Scientifique (CNRS), CNRS - National Institute for Biology (INSB), Universite de Strasbourg, CNRS, Insect Models Innate Immun M3I, UPR9022
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  • Olivier Lamiable, Univ Strasbourg, Universites de Strasbourg Etablissements Associes, Centre National de la Recherche Scientifique (CNRS), CNRS - National Institute for Biology (INSB), Universite de Strasbourg, CNRS, Insect Models Innate Immun M3I, UPR9022
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  • Laurent Troxler, Univ Strasbourg, Universites de Strasbourg Etablissements Associes, Centre National de la Recherche Scientifique (CNRS), CNRS - National Institute for Biology (INSB), Universite de Strasbourg, CNRS, Insect Models Innate Immun M3I, UPR9022
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  • Estelle Santiago, Univ Strasbourg, Universites de Strasbourg Etablissements Associes, Centre National de la Recherche Scientifique (CNRS), CNRS - National Institute for Biology (INSB), Universite de Strasbourg, CNRS, Insect Models Innate Immun M3I, UPR9022
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  • Lauriane Kuhn, Univ Strasbourg, Centre National de la Recherche Scientifique (CNRS), Universites de Strasbourg Etablissements Associes, Universite de Strasbourg, CNRS, Plateforme Prote Strasbourg Esplanade
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  • Donggi Paik, Univ Massachusetts, University of Massachusetts System, University of Massachusetts Worcester, Sch Med, Dept Med, Div Infect Dis & Immunol
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  • Neal Silverman, Univ Massachusetts, University of Massachusetts System, University of Massachusetts Worcester, Sch Med, Dept Med, Div Infect Dis & Immunol
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  • Andreas Holleufer
  • Rune Hartmann
  • Jiyong Liu, Guangzhou Med Univ, Guangzhou Medical University, Sino French Hoffmann Inst, Sch Basic Med Sci
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  • Tao Peng, Guangzhou Med Univ, Guangzhou Medical University, Sino French Hoffmann Inst, Sch Basic Med Sci
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  • Jules A. Hoffmann, Univ Strasbourg, Universite de Strasbourg, Universites de Strasbourg Etablissements Associes, Inst Adv Study
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  • Carine Meignin, Univ Strasbourg, Universites de Strasbourg Etablissements Associes, Centre National de la Recherche Scientifique (CNRS), CNRS - National Institute for Biology (INSB), Universite de Strasbourg, CNRS, Insect Models Innate Immun M3I, UPR9022
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  • Laurent Daeffler, Univ Strasbourg, Universites de Strasbourg Etablissements Associes, Centre National de la Recherche Scientifique (CNRS), CNRS - National Institute for Biology (INSB), Universite de Strasbourg, CNRS, Insect Models Innate Immun M3I, UPR9022
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  • Jean-Luc Imler, Guangzhou Med Univ, Guangzhou Medical University, Sino French Hoffmann Inst, Sch Basic Med Sci

Antiviral immunity in Drosophila involves RNA interference and poorly characterized inducible responses. Here, we showed that two components of the IMD pathway, the kinase dIKKβ and the transcription factor Relish, were required to control infection by two picorna-like viruses. We identified a set of genes induced by viral infection and regulated by dIKKβ and Relish, which included an ortholog of STING. We showed that dSTING participated in the control of infection by picorna-like viruses, acting upstream of dIKKβ to regulate expression of Nazo, an antiviral factor. Our data reveal an antiviral function for STING in an animal model devoid of interferons and suggest an evolutionarily ancient role for this molecule in antiviral immunity. Goto et al. show that the kinase dIKKβ and the NF-κB factor Relish control replication of picorna-like viruses in flies through induction of antiviral genes, including a homolog of STING. A STING-IKKβ-NF-κB cassette participates in resistance to picorna-like viruses, pointing to an evolutionarily ancient role of STING in antiviral immunity.

OriginalsprogEngelsk
TidsskriftImmunity
Vol/bind49
Nummer2
Sider (fra-til)225-234.e4
ISSN1074-7613
DOI
StatusUdgivet - 21 aug. 2018

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