TY - JOUR

T1 - The ins and outs of inhibitory synaptic plasticity

T2 - Neuron types, molecular mechanisms and functional roles

AU - Capogna, Marco

AU - Castillo, Pablo E.

AU - Maffei, Arianna

PY - 2020

Y1 - 2020

N2 - GABAergic interneurons are highly diverse, and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity-dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in learning and memory and circuit refinement. Here, we provide an updated overview of inhibitory synaptic plasticity with a focus on the hippocampus and neocortex. To illustrate the diversity of inhibitory interneurons, we discuss the case of two highly divergent interneuron types, parvalbumin-expressing basket cells and neurogliaform cells, which support unique roles on circuit dynamics. We also present recent progress on the molecular mechanisms underlying long-term, activity-dependent plasticity of fast inhibitory transmission. Lastly, we discuss the role of inhibitory synaptic plasticity in neuronal circuits' function. The emerging picture is that inhibitory synaptic transmission in the CNS is extremely diverse, undergoes various mechanistically distinct forms of plasticity and contributes to a much more refined computational role than initially thought. Both the remarkable diversity of inhibitory interneurons and the various forms of plasticity expressed by GABAergic synapses provide an amazingly rich inhibitory repertoire that is central to a variety of complex neural circuit functions, including memory.

AB - GABAergic interneurons are highly diverse, and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity-dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in learning and memory and circuit refinement. Here, we provide an updated overview of inhibitory synaptic plasticity with a focus on the hippocampus and neocortex. To illustrate the diversity of inhibitory interneurons, we discuss the case of two highly divergent interneuron types, parvalbumin-expressing basket cells and neurogliaform cells, which support unique roles on circuit dynamics. We also present recent progress on the molecular mechanisms underlying long-term, activity-dependent plasticity of fast inhibitory transmission. Lastly, we discuss the role of inhibitory synaptic plasticity in neuronal circuits' function. The emerging picture is that inhibitory synaptic transmission in the CNS is extremely diverse, undergoes various mechanistically distinct forms of plasticity and contributes to a much more refined computational role than initially thought. Both the remarkable diversity of inhibitory interneurons and the various forms of plasticity expressed by GABAergic synapses provide an amazingly rich inhibitory repertoire that is central to a variety of complex neural circuit functions, including memory.

KW - hippocampus

KW - memory

KW - neocortex

KW - neural circuits

KW - synaptic inhibition

KW - synaptic plasticity

KW - LONG-TERM POTENTIATION

KW - CRITICAL-PERIOD PLASTICITY

KW - PARVALBUMIN-EXPRESSING INTERNEURONS

KW - GABA(A) RECEPTOR TRAFFICKING

KW - HIPPOCAMPAL PYRAMIDAL CELLS

KW - TIMING-DEPENDENT PLASTICITY

KW - SPIKING GABAERGIC NEURONS

KW - VISUAL-CORTEX

KW - TRANSMITTER RELEASE

KW - NEUROTROPHIC FACTOR

U2 - 10.1111/ejn.14907

DO - 10.1111/ejn.14907

M3 - Review

C2 - 32663353

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

ER -