The increasing importance of Haemophilus influenzae in community-acquired pneumonia: results from a Danish cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

The increasing importance of Haemophilus influenzae in community-acquired pneumonia : results from a Danish cohort study. / Fally, Markus; Israelsen, Simone; Anhøj, Jacob; Benfield, Thomas; Tarp, Britta; Kolte, Lilian; Ravn, Pernille.

I: Infectious Diseases, Bind 53, Nr. 2, 02.2021, s. 122-130.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Fally, M, Israelsen, S, Anhøj, J, Benfield, T, Tarp, B, Kolte, L & Ravn, P 2021, 'The increasing importance of Haemophilus influenzae in community-acquired pneumonia: results from a Danish cohort study', Infectious Diseases, bind 53, nr. 2, s. 122-130. https://doi.org/10.1080/23744235.2020.1846776

APA

Fally, M., Israelsen, S., Anhøj, J., Benfield, T., Tarp, B., Kolte, L., & Ravn, P. (2021). The increasing importance of Haemophilus influenzae in community-acquired pneumonia: results from a Danish cohort study. Infectious Diseases, 53(2), 122-130. https://doi.org/10.1080/23744235.2020.1846776

CBE

MLA

Vancouver

Author

Fally, Markus ; Israelsen, Simone ; Anhøj, Jacob ; Benfield, Thomas ; Tarp, Britta ; Kolte, Lilian ; Ravn, Pernille. / The increasing importance of Haemophilus influenzae in community-acquired pneumonia : results from a Danish cohort study. I: Infectious Diseases. 2021 ; Bind 53, Nr. 2. s. 122-130.

Bibtex

@article{b0abdb423efe401f8e5c7dd7ac36d7d4,
title = "The increasing importance of Haemophilus influenzae in community-acquired pneumonia: results from a Danish cohort study",
abstract = "BACKGROUND: Numerous studies have shown that the aetiology of community-acquired pneumonia (CAP) varies considerably among different healthcare settings. Because empiric therapies for CAP should cover the major pathogens, reports examining CAP aetiology are considered crucial, particularly in Nordic countries that still rely on penicillin G or V treatments for most patients with CAP. The primary objective of our study was to report CAP aetiology. Secondary objectives included the estimation of positivity rates for different tests and the odds of a positive test for various subgroups.METHODS: In this cohort study, microbiological data were analysed for an overall cohort (variable degree of microbiological testing) and for a subgroup that was tested for both, bacteria, viruses and fungi, using routine methods (defined as extensive testing).RESULTS: The overall cohort comprised 2,264 patients, including 315 who were extensively tested. Bacterial and viral monoinfections were the most commonly identified infections. The dominant pathogen identified among extensively tested patients was Haemophilus influenzae (23.7%), followed by Streptococcus pneumoniae (20.6%). The tests with the highest positivity rates were sputum cultures (34.7%) and viral polymerase chain reaction (PCR, 24.4%). The odds of achieving a microbiological diagnosis increased significantly when extensive testing was performed compared with selective testing (OR 2.86, 95% CI 2.24-3.64).CONCLUSION: Our study indicated that H. influenzae is the dominant responsible pathogen for bacterial CAP in Denmark. Thus, we believe that the current treatment recommendations that encourage the use of penicillin G or V for the majority of patients with CAP need to be revised.",
author = "Markus Fally and Simone Israelsen and Jacob Anh{\o}j and Thomas Benfield and Britta Tarp and Lilian Kolte and Pernille Ravn",
year = "2021",
month = feb,
doi = "10.1080/23744235.2020.1846776",
language = "English",
volume = "53",
pages = "122--130",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Informa Healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - The increasing importance of Haemophilus influenzae in community-acquired pneumonia

T2 - results from a Danish cohort study

AU - Fally, Markus

AU - Israelsen, Simone

AU - Anhøj, Jacob

AU - Benfield, Thomas

AU - Tarp, Britta

AU - Kolte, Lilian

AU - Ravn, Pernille

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: Numerous studies have shown that the aetiology of community-acquired pneumonia (CAP) varies considerably among different healthcare settings. Because empiric therapies for CAP should cover the major pathogens, reports examining CAP aetiology are considered crucial, particularly in Nordic countries that still rely on penicillin G or V treatments for most patients with CAP. The primary objective of our study was to report CAP aetiology. Secondary objectives included the estimation of positivity rates for different tests and the odds of a positive test for various subgroups.METHODS: In this cohort study, microbiological data were analysed for an overall cohort (variable degree of microbiological testing) and for a subgroup that was tested for both, bacteria, viruses and fungi, using routine methods (defined as extensive testing).RESULTS: The overall cohort comprised 2,264 patients, including 315 who were extensively tested. Bacterial and viral monoinfections were the most commonly identified infections. The dominant pathogen identified among extensively tested patients was Haemophilus influenzae (23.7%), followed by Streptococcus pneumoniae (20.6%). The tests with the highest positivity rates were sputum cultures (34.7%) and viral polymerase chain reaction (PCR, 24.4%). The odds of achieving a microbiological diagnosis increased significantly when extensive testing was performed compared with selective testing (OR 2.86, 95% CI 2.24-3.64).CONCLUSION: Our study indicated that H. influenzae is the dominant responsible pathogen for bacterial CAP in Denmark. Thus, we believe that the current treatment recommendations that encourage the use of penicillin G or V for the majority of patients with CAP need to be revised.

AB - BACKGROUND: Numerous studies have shown that the aetiology of community-acquired pneumonia (CAP) varies considerably among different healthcare settings. Because empiric therapies for CAP should cover the major pathogens, reports examining CAP aetiology are considered crucial, particularly in Nordic countries that still rely on penicillin G or V treatments for most patients with CAP. The primary objective of our study was to report CAP aetiology. Secondary objectives included the estimation of positivity rates for different tests and the odds of a positive test for various subgroups.METHODS: In this cohort study, microbiological data were analysed for an overall cohort (variable degree of microbiological testing) and for a subgroup that was tested for both, bacteria, viruses and fungi, using routine methods (defined as extensive testing).RESULTS: The overall cohort comprised 2,264 patients, including 315 who were extensively tested. Bacterial and viral monoinfections were the most commonly identified infections. The dominant pathogen identified among extensively tested patients was Haemophilus influenzae (23.7%), followed by Streptococcus pneumoniae (20.6%). The tests with the highest positivity rates were sputum cultures (34.7%) and viral polymerase chain reaction (PCR, 24.4%). The odds of achieving a microbiological diagnosis increased significantly when extensive testing was performed compared with selective testing (OR 2.86, 95% CI 2.24-3.64).CONCLUSION: Our study indicated that H. influenzae is the dominant responsible pathogen for bacterial CAP in Denmark. Thus, we believe that the current treatment recommendations that encourage the use of penicillin G or V for the majority of patients with CAP need to be revised.

U2 - 10.1080/23744235.2020.1846776

DO - 10.1080/23744235.2020.1846776

M3 - Journal article

C2 - 33231116

VL - 53

SP - 122

EP - 130

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 2

ER -