The impact of a tailored follow-up intervention on comprehensive geriatric assessment in older patients with cancer - a randomised controlled trial

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The impact of a tailored follow-up intervention on comprehensive geriatric assessment in older patients with cancer - a randomised controlled trial. / Ørum, Marianne; Eriksen, Stine Vestergaard; Gregersen, Merete; Jensen, Anni Ravnsbæk; Jensen, Kenneth; Meldgaard, Peter; Nordsmark, Marianne; Damsgaard, Else Marie.

I: Journal of Geriatric Oncology, Bind 12, Nr. 1, 01.2021, s. 41-48.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{2b5ef2d5491243fba8aa9f77a42ff6f6,
title = "The impact of a tailored follow-up intervention on comprehensive geriatric assessment in older patients with cancer - a randomised controlled trial",
abstract = "Purpose: Comprehensive Geriatric Assessment (CGA) can identify health problems in older persons. In addition, CGA includes intervention towards the identified problems. With follow up, more problems may be identified and the interventions can be adjusted. We wanted to compare CGA with or without tailored follow-up in a randomised design. Patients and Methods: Patients 70+ years referred for oncology treatment with four primary tumour sites. Participants were randomised 1:1 to either control group with no follow-up or intervention group with a tailored follow-up by a multidisciplinary team. Primary outcome was adherence to cancer treatment. Secondary outcomes were daily life activities, physical performance and hospitalisation. Results: In total, 363 participants were randomised. After randomisation only 301 were planned to receive specific cancer treatment. Median age was 75 years. Among the 301 participants, 52% of control group vs. 61% of intervention group completed treatment. Risk Rate (RR): 1.16 (95% Confidence Interval (CI): 0.95–1.42), p = .14. The impact varied between the included tumour-sites, p < .01. We found no difference in 90 days physical performance or daily life activities between groups. During the study period, 55% of controls vs. 47% in the intervention group were admitted to hospital, RR: 0.86 (95%CI: 0.69–1.07), p = .19. Conclusion: In frail and vulnerable patients with cancer, a tailored follow-up on CGA showed no differences in ability to complete initially planned cancer treatment. The impact varied between the included tumour sites. We did not find any impact of tailored follow-up on daily life activities, physical performance or hospitalisation.",
keywords = "Adherence to treatment, Completion of treatment, Comprehensive geriatric assessment, Geriatric interventions, Randomised controlled trial, Survival",
author = "Marianne {\O}rum and Eriksen, {Stine Vestergaard} and Merete Gregersen and Jensen, {Anni Ravnsb{\ae}k} and Kenneth Jensen and Peter Meldgaard and Marianne Nordsmark and Damsgaard, {Else Marie}",
year = "2021",
month = jan,
doi = "10.1016/j.jgo.2020.07.011",
language = "English",
volume = "12",
pages = "41--48",
journal = "Journal of Geriatric Oncology",
issn = "1879-4068",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - The impact of a tailored follow-up intervention on comprehensive geriatric assessment in older patients with cancer - a randomised controlled trial

AU - Ørum, Marianne

AU - Eriksen, Stine Vestergaard

AU - Gregersen, Merete

AU - Jensen, Anni Ravnsbæk

AU - Jensen, Kenneth

AU - Meldgaard, Peter

AU - Nordsmark, Marianne

AU - Damsgaard, Else Marie

PY - 2021/1

Y1 - 2021/1

N2 - Purpose: Comprehensive Geriatric Assessment (CGA) can identify health problems in older persons. In addition, CGA includes intervention towards the identified problems. With follow up, more problems may be identified and the interventions can be adjusted. We wanted to compare CGA with or without tailored follow-up in a randomised design. Patients and Methods: Patients 70+ years referred for oncology treatment with four primary tumour sites. Participants were randomised 1:1 to either control group with no follow-up or intervention group with a tailored follow-up by a multidisciplinary team. Primary outcome was adherence to cancer treatment. Secondary outcomes were daily life activities, physical performance and hospitalisation. Results: In total, 363 participants were randomised. After randomisation only 301 were planned to receive specific cancer treatment. Median age was 75 years. Among the 301 participants, 52% of control group vs. 61% of intervention group completed treatment. Risk Rate (RR): 1.16 (95% Confidence Interval (CI): 0.95–1.42), p = .14. The impact varied between the included tumour-sites, p < .01. We found no difference in 90 days physical performance or daily life activities between groups. During the study period, 55% of controls vs. 47% in the intervention group were admitted to hospital, RR: 0.86 (95%CI: 0.69–1.07), p = .19. Conclusion: In frail and vulnerable patients with cancer, a tailored follow-up on CGA showed no differences in ability to complete initially planned cancer treatment. The impact varied between the included tumour sites. We did not find any impact of tailored follow-up on daily life activities, physical performance or hospitalisation.

AB - Purpose: Comprehensive Geriatric Assessment (CGA) can identify health problems in older persons. In addition, CGA includes intervention towards the identified problems. With follow up, more problems may be identified and the interventions can be adjusted. We wanted to compare CGA with or without tailored follow-up in a randomised design. Patients and Methods: Patients 70+ years referred for oncology treatment with four primary tumour sites. Participants were randomised 1:1 to either control group with no follow-up or intervention group with a tailored follow-up by a multidisciplinary team. Primary outcome was adherence to cancer treatment. Secondary outcomes were daily life activities, physical performance and hospitalisation. Results: In total, 363 participants were randomised. After randomisation only 301 were planned to receive specific cancer treatment. Median age was 75 years. Among the 301 participants, 52% of control group vs. 61% of intervention group completed treatment. Risk Rate (RR): 1.16 (95% Confidence Interval (CI): 0.95–1.42), p = .14. The impact varied between the included tumour-sites, p < .01. We found no difference in 90 days physical performance or daily life activities between groups. During the study period, 55% of controls vs. 47% in the intervention group were admitted to hospital, RR: 0.86 (95%CI: 0.69–1.07), p = .19. Conclusion: In frail and vulnerable patients with cancer, a tailored follow-up on CGA showed no differences in ability to complete initially planned cancer treatment. The impact varied between the included tumour sites. We did not find any impact of tailored follow-up on daily life activities, physical performance or hospitalisation.

KW - Adherence to treatment

KW - Completion of treatment

KW - Comprehensive geriatric assessment

KW - Geriatric interventions

KW - Randomised controlled trial

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85088868166&partnerID=8YFLogxK

U2 - 10.1016/j.jgo.2020.07.011

DO - 10.1016/j.jgo.2020.07.011

M3 - Journal article

C2 - 32747208

AN - SCOPUS:85088868166

VL - 12

SP - 41

EP - 48

JO - Journal of Geriatric Oncology

JF - Journal of Geriatric Oncology

SN - 1879-4068

IS - 1

ER -