The immunohistological localization of the different components of the plasminogen activation system in breast cancer

Lise Christensen*, Pia Møller Martensen, Peter Andreasen

*Corresponding author af dette arbejde

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    In order to determine the cell types involved in the functions of the plasminogen activation system in cancer we have immunohistochemically stained a series of invasive breast carcinomas for the presence of u-PA, PAI-1, u-PAR, alpha-2 MR/LRP and VLDL-R. u-PA and PAI-1 were similarly expressed in benign and malignant breast cells, fibroblastic cells, endothelial cells and macrophages/mast cells, most intensely in the latter 2 cell types Also u-PAR was intensely expressed in all macrophages and mast cells, but other than that it was only seen in some malignant epithelial cells bordering host connective tissue and a few fibroblastic cells. The alpha-2 macroglobulin receptor (LRP), which can internalize and degrade u-PAR bound u-PA/PAI-1 complexes, was present in all fibroblastic cells, some macrophages and mast cells, and the very-low-density lipoprotein receptor (VLDL-R), which has a similar function, was mainly present in epithelial cells, macrophages and mast cells. The fact that all the studied components of the plasminogen activation process are intensely expressed in macrophages/mast cells suggests an increased activity of these components to take place. However, the cause for increased activity may be different within the different cells, as the components are active in a multitude of functions. We believe that only the tumor cell u-PA, PAI-1, u-PAR and VLDL-R reflect a direct function in cancer cell migration and invasion. Differential expression of the various components by different other, benign cell types may reflect a role of the u-pPA system in cancer-cell directed tissue-remodelling like desmoplasia and angiogenesis.

    TidsskriftFibrinolysis and Proteolysis
    NummerSUPPL. 3
    Antal sider1
    StatusUdgivet - 1 dec. 1997


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