The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Tenna Juul Schrøder; Søren Christensen; Samsa Lindberg; Morten Langgård; Laurent David; Philip J Maltas; Jørgen Eskildsen; Jan Jacobsen; Lena Tagmose; Klaus Bæk Simonsen; Lars Christian Biilmann Rønn; Inge Elisabeth Maria de Jong; Ibrahim J Malik; Jens-Jakob Karlsson; Christoffer Bundgaard; Jan Egebjerg; Jeffrey B Stavenhagen; Dorthe Strandbygård; Søren Skou Thirup; Jacob Lauwring Andersen; Srinivas Uppalanchi; Sridhar Pervaram; Shiva Prasad Kasturi; Pradheep Eradi; Durga Rao Sakumudi; Stephen Paul Watson

doi:10.1016/j.bmcl.2013.11.046

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Tenna Juul Schrøder, Søren Christensen, Samsa Lindberg, Morten Langgård, Laurent David, Philip J Maltas, Jørgen Eskildsen, Jan Jacobsen, Lena Tagmose, Klaus Bæk Simonsen, Lars Christian Biilmann Rønn, Inge Elisabeth Maria de Jong, Ibrahim J Malik, Jens-Jakob Karlsson, Christoffer Bundgaard, Jan Egebjerg, Jeffrey B Stavenhagen, Dorthe Strandbygård, Søren Skou Thirup, Jacob Lauwring AndersenSrinivas Uppalanchi, Sridhar Pervaram, Shiva Prasad Kasturi, Pradheep Eradi, Durga Rao Sakumudi, Stephen Paul Watson

Institut for Molekylærbiologi og Genetik - Neurobiologi

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

36 Citationer (Scopus)

Abstract

The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.

Originalsprog	Engelsk
Tidsskrift	Bioorganic & Medicinal Chemistry Letters
Vol/bind	24
Nummer	1
Sider (fra-til)	177-180
Antal sider	4
ISSN	0960-894X
DOI	https://doi.org/10.1016/j.bmcl.2013.11.046
Status	Udgivet - 1 jan. 2014

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10.1016/j.bmcl.2013.11.046

Citationsformater

Schrøder, T. J., Christensen, S., Lindberg, S., Langgård, M., David, L., Maltas, P. J., Eskildsen, J., Jacobsen, J., Tagmose, L., Simonsen, K. B., Biilmann Rønn, L. C., de Jong, I. E. M., Malik, I. J., Karlsson, J.-J., Bundgaard, C., Egebjerg, J., Stavenhagen, J. B., Strandbygård, D., Thirup, S. S., ... Watson, S. P. (2014). The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorganic & Medicinal Chemistry Letters, 24(1), 177-180. https://doi.org/10.1016/j.bmcl.2013.11.046

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title = "The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin",

abstract = "The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.",

author = "Schr{\o}der, {Tenna Juul} and S{\o}ren Christensen and Samsa Lindberg and Morten Langg{\aa}rd and Laurent David and Maltas, {Philip J} and J{\o}rgen Eskildsen and Jan Jacobsen and Lena Tagmose and Simonsen, {Klaus B{\ae}k} and {Biilmann R{\o}nn}, {Lars Christian} and {de Jong}, {Inge Elisabeth Maria} and Malik, {Ibrahim J} and Jens-Jakob Karlsson and Christoffer Bundgaard and Jan Egebjerg and Stavenhagen, {Jeffrey B} and Dorthe Strandbyg{\aa}rd and Thirup, {S{\o}ren Skou} and Andersen, {Jacob Lauwring} and Srinivas Uppalanchi and Sridhar Pervaram and Kasturi, {Shiva Prasad} and Pradheep Eradi and Sakumudi, {Durga Rao} and Watson, {Stephen Paul}",

year = "2014",

month = jan,

day = "1",

doi = "10.1016/j.bmcl.2013.11.046",

language = "English",

volume = "24",

pages = "177--180",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "1",

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Schrøder, TJ, Christensen, S, Lindberg, S, Langgård, M, David, L, Maltas, PJ, Eskildsen, J, Jacobsen, J, Tagmose, L, Simonsen, KB, Biilmann Rønn, LC, de Jong, IEM, Malik, IJ, Karlsson, J-J, Bundgaard, C, Egebjerg, J, Stavenhagen, JB, Strandbygård, D , Thirup, SS, Andersen, JL, Uppalanchi, S, Pervaram, S, Kasturi, SP, Eradi, P, Sakumudi, DR & Watson, SP 2014, 'The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin', Bioorganic & Medicinal Chemistry Letters, bind 24, nr. 1, s. 177-180. https://doi.org/10.1016/j.bmcl.2013.11.046

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. / Schrøder, Tenna Juul; Christensen, Søren; Lindberg, Samsa et al.
I: Bioorganic & Medicinal Chemistry Letters, Bind 24, Nr. 1, 01.01.2014, s. 177-180.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

T2 - An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

AU - Schrøder, Tenna Juul

AU - Christensen, Søren

AU - Lindberg, Samsa

AU - Langgård, Morten

AU - David, Laurent

AU - Maltas, Philip J

AU - Eskildsen, Jørgen

AU - Jacobsen, Jan

AU - Tagmose, Lena

AU - Simonsen, Klaus Bæk

AU - Biilmann Rønn, Lars Christian

AU - de Jong, Inge Elisabeth Maria

AU - Malik, Ibrahim J

AU - Karlsson, Jens-Jakob

AU - Bundgaard, Christoffer

AU - Egebjerg, Jan

AU - Stavenhagen, Jeffrey B

AU - Strandbygård, Dorthe

AU - Thirup, Søren Skou

AU - Andersen, Jacob Lauwring

AU - Uppalanchi, Srinivas

AU - Pervaram, Sridhar

AU - Kasturi, Shiva Prasad

AU - Eradi, Pradheep

AU - Sakumudi, Durga Rao

AU - Watson, Stephen Paul

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.

AB - The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.

U2 - 10.1016/j.bmcl.2013.11.046

DO - 10.1016/j.bmcl.2013.11.046

M3 - Journal article

C2 - 24355129

SN - 0960-894X

VL - 24

SP - 177

EP - 180

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 1

ER -

Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ et al. The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorganic & Medicinal Chemistry Letters. 2014 jan. 1;24(1):177-180. doi: 10.1016/j.bmcl.2013.11.046

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Abstract

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