The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Tenna Juul Schrøder, Søren Christensen, Samsa Lindberg, Morten Langgård, Laurent David, Philip J Maltas, Jørgen Eskildsen, Jan Jacobsen, Lena Tagmose, Klaus Bæk Simonsen, Lars Christian Biilmann Rønn, Inge Elisabeth Maria de Jong, Ibrahim J Malik, Jens-Jakob Karlsson, Christoffer Bundgaard, Jan Egebjerg, Jeffrey B Stavenhagen, Dorthe Strandbygård, Søren Skou Thirup, Jacob Lauwring AndersenSrinivas Uppalanchi, Sridhar Pervaram, Shiva Prasad Kasturi, Pradheep Eradi, Durga Rao Sakumudi, Stephen Paul Watson

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Abstract

The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.
OriginalsprogEngelsk
TidsskriftBioorganic & Medicinal Chemistry Letters
Vol/bind24
Nummer1
Sider (fra-til)177-180
Antal sider4
ISSN0960-894X
DOI
StatusUdgivet - 1 jan. 2014

Fingeraftryk

Dyk ned i forskningsemnerne om 'The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin'. Sammen danner de et unikt fingeraftryk.

Citationsformater