The Human Eye Proteome Project: Perspectives on an emerging proteome

TY - JOUR

T1 - The Human Eye Proteome Project

T2 - Perspectives on an emerging proteome

AU - Semba, Richard D

AU - Enghild, Jan Johannes

AU - Venkatraman, Vidya

AU - Dyrlund, Thomas F

AU - Van Eyk, Jennifer E

N1 - This article is protected by copyright. All rights reserved.

PY - 2013/6/10

Y1 - 2013/6/10

N2 - There are an estimated 285 million people with visual impairment worldwide, of whom 39 million are blind. The pathogenesis of many eye diseases remains poorly understood. The human eye is currently an emerging proteome that may provide key insight into the biological pathways of disease. We review proteomic investigations of the human eye and present a catalogue of 4842 non-redundant proteins identified in human eye tissues and biofluids to date. We highlight the need to identify new biomarkers for eye diseases using proteomics. Recent advances in proteomics now allow the identification of hundreds to thousands of proteins in tissues and fluids, characterization of various post-translational modifications, and simultaneous quantification of multiple proteins. To facilitate proteomic studies of the eye, the Human Eye Proteome Project (HEPP) was organized in September 2012. The HEPP is one of the most recent components of the Biology/Disease-driven Human Proteome Project (B/D-HPP) whose overarching goal is to support the broad application of state-of-the-art measurements of proteins and proteomes by life scientists studying the molecular mechanisms of biological processes and human disease. The large repertoire of investigative proteomic tools has great potential to transform vision science and enhance understanding of physiology and disease processes that affect sight. This article is protected by copyright. All rights reserved.

AB - There are an estimated 285 million people with visual impairment worldwide, of whom 39 million are blind. The pathogenesis of many eye diseases remains poorly understood. The human eye is currently an emerging proteome that may provide key insight into the biological pathways of disease. We review proteomic investigations of the human eye and present a catalogue of 4842 non-redundant proteins identified in human eye tissues and biofluids to date. We highlight the need to identify new biomarkers for eye diseases using proteomics. Recent advances in proteomics now allow the identification of hundreds to thousands of proteins in tissues and fluids, characterization of various post-translational modifications, and simultaneous quantification of multiple proteins. To facilitate proteomic studies of the eye, the Human Eye Proteome Project (HEPP) was organized in September 2012. The HEPP is one of the most recent components of the Biology/Disease-driven Human Proteome Project (B/D-HPP) whose overarching goal is to support the broad application of state-of-the-art measurements of proteins and proteomes by life scientists studying the molecular mechanisms of biological processes and human disease. The large repertoire of investigative proteomic tools has great potential to transform vision science and enhance understanding of physiology and disease processes that affect sight. This article is protected by copyright. All rights reserved.

U2 - 10.1002/pmic.201300075

DO - 10.1002/pmic.201300075

M3 - Journal article

C2 - 23749747

SN - 1615-9853

VL - 13

SP - 2500

EP - 2511

JO - Proteomics

JF - Proteomics

IS - 16

ER -