The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health

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The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health. / Li, Zhencheng; Rasmussen, Torben Solbeck; Rasmussen, Mette Line; Li, Jingwen; Olguin, Carlos Henriquez; Kot, Witold; Nielsen, Dennis Sandris; Jensen, Thomas Elbenhardt.

I: Frontiers in Microbiology, Bind 10, 709, 04.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Li, Z, Rasmussen, TS, Rasmussen, ML, Li, J, Olguin, CH, Kot, W, Nielsen, DS & Jensen, TE 2019, 'The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health', Frontiers in Microbiology, bind 10, 709. https://doi.org/10.3389/fmicb.2019.00709

APA

Li, Z., Rasmussen, T. S., Rasmussen, M. L., Li, J., Olguin, C. H., Kot, W., Nielsen, D. S., & Jensen, T. E. (2019). The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health. Frontiers in Microbiology, 10, [709]. https://doi.org/10.3389/fmicb.2019.00709

CBE

Li Z, Rasmussen TS, Rasmussen ML, Li J, Olguin CH, Kot W, Nielsen DS, Jensen TE. 2019. The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health. Frontiers in Microbiology. 10:Article 709. https://doi.org/10.3389/fmicb.2019.00709

MLA

Vancouver

Li Z, Rasmussen TS, Rasmussen ML, Li J, Olguin CH, Kot W o.a. The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health. Frontiers in Microbiology. 2019 apr;10. 709. https://doi.org/10.3389/fmicb.2019.00709

Author

Li, Zhencheng ; Rasmussen, Torben Solbeck ; Rasmussen, Mette Line ; Li, Jingwen ; Olguin, Carlos Henriquez ; Kot, Witold ; Nielsen, Dennis Sandris ; Jensen, Thomas Elbenhardt. / The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health. I: Frontiers in Microbiology. 2019 ; Bind 10.

Bibtex

@article{08ce8f207c654a21acb4e5161360e9c7,
title = "The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health",
abstract = "A periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet protects against weight gain, improves glucose tolerance in mice and interacts with concurrent voluntary activity wheel training on several parameters including weight maintenance and liver FGF21 secretion. The gut microbiome (GM) responds to both diet and exercise and may influence host metabolism. This study compared the cecal GM after a 13.5-week intervention study in mice on a variety of dietary interventions +/- concurrent voluntary exercise training in activity wheels. The diets included chronic chow diet, LPHC diet, 40 E% high protein-low carbohydrate (HPLC) diet, an obesigenic chronic high-fat diet (HFD) and the pLPHC diet. Our hypothesis was that the GM changes with pLPHC diet would generally reflect the improved metabolic health of the host and interact with concurrent exercise training. The GM analyses revealed greater abundance phylum Bacteroidetes and the genus Akkermansia on chronic and periodized LPHC and higher abundance of Oscillospira and Oscillibacter on HFD. The differences in diet-induced GM correlated strongly with the differences in a range of host metabolic health-measures. In contrast, no significant effect of concurrent exercise training was observed. In conclusion, pLPHC diet elicits substantial changes in the GM. In contrast, only subtle and non-significant effects of concurrent activity wheel exercise were observed. The pLPHC-associated microbiome may contribute to the healthier host phenotype observed in these mice.",
keywords = "microbiome, exercise, low protein diet, periodized, intermittent, HIGH-FAT DIET, INSULIN-RESISTANCE, OBESITY, EXERCISE, INFLAMMATION, SIGNATURE, RECEPTOR, RATIO",
author = "Zhencheng Li and Rasmussen, {Torben Solbeck} and Rasmussen, {Mette Line} and Jingwen Li and Olguin, {Carlos Henriquez} and Witold Kot and Nielsen, {Dennis Sandris} and Jensen, {Thomas Elbenhardt}",
year = "2019",
month = apr,
doi = "10.3389/fmicb.2019.00709",
language = "English",
volume = "10",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A",

}

RIS

TY - JOUR

T1 - The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health

AU - Li, Zhencheng

AU - Rasmussen, Torben Solbeck

AU - Rasmussen, Mette Line

AU - Li, Jingwen

AU - Olguin, Carlos Henriquez

AU - Kot, Witold

AU - Nielsen, Dennis Sandris

AU - Jensen, Thomas Elbenhardt

PY - 2019/4

Y1 - 2019/4

N2 - A periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet protects against weight gain, improves glucose tolerance in mice and interacts with concurrent voluntary activity wheel training on several parameters including weight maintenance and liver FGF21 secretion. The gut microbiome (GM) responds to both diet and exercise and may influence host metabolism. This study compared the cecal GM after a 13.5-week intervention study in mice on a variety of dietary interventions +/- concurrent voluntary exercise training in activity wheels. The diets included chronic chow diet, LPHC diet, 40 E% high protein-low carbohydrate (HPLC) diet, an obesigenic chronic high-fat diet (HFD) and the pLPHC diet. Our hypothesis was that the GM changes with pLPHC diet would generally reflect the improved metabolic health of the host and interact with concurrent exercise training. The GM analyses revealed greater abundance phylum Bacteroidetes and the genus Akkermansia on chronic and periodized LPHC and higher abundance of Oscillospira and Oscillibacter on HFD. The differences in diet-induced GM correlated strongly with the differences in a range of host metabolic health-measures. In contrast, no significant effect of concurrent exercise training was observed. In conclusion, pLPHC diet elicits substantial changes in the GM. In contrast, only subtle and non-significant effects of concurrent activity wheel exercise were observed. The pLPHC-associated microbiome may contribute to the healthier host phenotype observed in these mice.

AB - A periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet protects against weight gain, improves glucose tolerance in mice and interacts with concurrent voluntary activity wheel training on several parameters including weight maintenance and liver FGF21 secretion. The gut microbiome (GM) responds to both diet and exercise and may influence host metabolism. This study compared the cecal GM after a 13.5-week intervention study in mice on a variety of dietary interventions +/- concurrent voluntary exercise training in activity wheels. The diets included chronic chow diet, LPHC diet, 40 E% high protein-low carbohydrate (HPLC) diet, an obesigenic chronic high-fat diet (HFD) and the pLPHC diet. Our hypothesis was that the GM changes with pLPHC diet would generally reflect the improved metabolic health of the host and interact with concurrent exercise training. The GM analyses revealed greater abundance phylum Bacteroidetes and the genus Akkermansia on chronic and periodized LPHC and higher abundance of Oscillospira and Oscillibacter on HFD. The differences in diet-induced GM correlated strongly with the differences in a range of host metabolic health-measures. In contrast, no significant effect of concurrent exercise training was observed. In conclusion, pLPHC diet elicits substantial changes in the GM. In contrast, only subtle and non-significant effects of concurrent activity wheel exercise were observed. The pLPHC-associated microbiome may contribute to the healthier host phenotype observed in these mice.

KW - microbiome

KW - exercise

KW - low protein diet

KW - periodized

KW - intermittent

KW - HIGH-FAT DIET

KW - INSULIN-RESISTANCE

KW - OBESITY

KW - EXERCISE

KW - INFLAMMATION

KW - SIGNATURE

KW - RECEPTOR

KW - RATIO

U2 - 10.3389/fmicb.2019.00709

DO - 10.3389/fmicb.2019.00709

M3 - Journal article

C2 - 31019501

VL - 10

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

M1 - 709

ER -