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The Future of Cryopreservation in Assisted Reproductive Technologies

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The Future of Cryopreservation in Assisted Reproductive Technologies. / Bosch, Ernesto; De Vos, Michel; Humaidan, Peter.

I: Frontiers in Endocrinology, Bind 11, 67, 02.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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Bosch, Ernesto ; De Vos, Michel ; Humaidan, Peter. / The Future of Cryopreservation in Assisted Reproductive Technologies. I: Frontiers in Endocrinology. 2020 ; Bind 11.

Bibtex

@article{e5c22a01d8b54ff6aebbf9242f412d76,
title = "The Future of Cryopreservation in Assisted Reproductive Technologies",
abstract = "Societal changes and the increasing desire and opportunity to preserve fertility have increased the demand for effective assisted reproductive technologies (ART) and have increased the range of scenarios in which ART is now used. In recent years, the “freeze-all” strategy of cryopreserving all oocytes or good quality embryos produced in an IVF cycle to transfer later—at a time that is more appropriate for reasons of medical need, efficacy, or desirability—has emerged as an accepted and valuable alternative to fresh embryo transfer. Indeed, improvements in cryopreservation techniques (vitrification) and the development of more efficient ovarian stimulation protocols have facilitated a dramatic increase in the practice of elective frozen embryo transfer (eFET). Alongside these advances, debate continues about whether eFET should be a standard treatment option available to the whole IVF population or if it is important to identify patient subgroups who are most likely to benefit from such an approach. Achieving successful outcomes in ART, whether by fresh or frozen embryo transfer, is influenced by a wide range of factors. As well as the efficiency of IVF and embryo transfer protocols and techniques, factors affecting implantation include maternal aging, sperm quality, the vaginal and endometrial microbiome, and peri-implantation levels of serum progesterone. The safety of eFET, both during ART cycles and on longer-term obstetric and neonatal outcomes, is also an important consideration. In this review, we explore the benefits and risks of freeze-all strategies in different scenarios. We review available evidence on the outcomes achieved with elective cryopreservation strategies and practices and how these compare with more traditional IVF cycles with fresh embryo transfers, both in the general IVF population and in subgroups of special interest. In addition, we consider how to optimize and individualize “freeze-all” procedures to achieve successful reproductive outcomes.",
keywords = "elective frozen embryo transfer (eFET), embryo cryopreservation, freeze-all, high responders, oocyte cryopreservation, ovarian hyperstimulation syndrome (OHSS), polycystic ovary syndrome (PCOS), preimplantation genetic testing (PGT)",
author = "Ernesto Bosch and {De Vos}, Michel and Peter Humaidan",
year = "2020",
month = feb,
doi = "10.3389/fendo.2020.00067",
language = "English",
volume = "11",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S.A",

}

RIS

TY - JOUR

T1 - The Future of Cryopreservation in Assisted Reproductive Technologies

AU - Bosch, Ernesto

AU - De Vos, Michel

AU - Humaidan, Peter

PY - 2020/2

Y1 - 2020/2

N2 - Societal changes and the increasing desire and opportunity to preserve fertility have increased the demand for effective assisted reproductive technologies (ART) and have increased the range of scenarios in which ART is now used. In recent years, the “freeze-all” strategy of cryopreserving all oocytes or good quality embryos produced in an IVF cycle to transfer later—at a time that is more appropriate for reasons of medical need, efficacy, or desirability—has emerged as an accepted and valuable alternative to fresh embryo transfer. Indeed, improvements in cryopreservation techniques (vitrification) and the development of more efficient ovarian stimulation protocols have facilitated a dramatic increase in the practice of elective frozen embryo transfer (eFET). Alongside these advances, debate continues about whether eFET should be a standard treatment option available to the whole IVF population or if it is important to identify patient subgroups who are most likely to benefit from such an approach. Achieving successful outcomes in ART, whether by fresh or frozen embryo transfer, is influenced by a wide range of factors. As well as the efficiency of IVF and embryo transfer protocols and techniques, factors affecting implantation include maternal aging, sperm quality, the vaginal and endometrial microbiome, and peri-implantation levels of serum progesterone. The safety of eFET, both during ART cycles and on longer-term obstetric and neonatal outcomes, is also an important consideration. In this review, we explore the benefits and risks of freeze-all strategies in different scenarios. We review available evidence on the outcomes achieved with elective cryopreservation strategies and practices and how these compare with more traditional IVF cycles with fresh embryo transfers, both in the general IVF population and in subgroups of special interest. In addition, we consider how to optimize and individualize “freeze-all” procedures to achieve successful reproductive outcomes.

AB - Societal changes and the increasing desire and opportunity to preserve fertility have increased the demand for effective assisted reproductive technologies (ART) and have increased the range of scenarios in which ART is now used. In recent years, the “freeze-all” strategy of cryopreserving all oocytes or good quality embryos produced in an IVF cycle to transfer later—at a time that is more appropriate for reasons of medical need, efficacy, or desirability—has emerged as an accepted and valuable alternative to fresh embryo transfer. Indeed, improvements in cryopreservation techniques (vitrification) and the development of more efficient ovarian stimulation protocols have facilitated a dramatic increase in the practice of elective frozen embryo transfer (eFET). Alongside these advances, debate continues about whether eFET should be a standard treatment option available to the whole IVF population or if it is important to identify patient subgroups who are most likely to benefit from such an approach. Achieving successful outcomes in ART, whether by fresh or frozen embryo transfer, is influenced by a wide range of factors. As well as the efficiency of IVF and embryo transfer protocols and techniques, factors affecting implantation include maternal aging, sperm quality, the vaginal and endometrial microbiome, and peri-implantation levels of serum progesterone. The safety of eFET, both during ART cycles and on longer-term obstetric and neonatal outcomes, is also an important consideration. In this review, we explore the benefits and risks of freeze-all strategies in different scenarios. We review available evidence on the outcomes achieved with elective cryopreservation strategies and practices and how these compare with more traditional IVF cycles with fresh embryo transfers, both in the general IVF population and in subgroups of special interest. In addition, we consider how to optimize and individualize “freeze-all” procedures to achieve successful reproductive outcomes.

KW - elective frozen embryo transfer (eFET)

KW - embryo cryopreservation

KW - freeze-all

KW - high responders

KW - oocyte cryopreservation

KW - ovarian hyperstimulation syndrome (OHSS)

KW - polycystic ovary syndrome (PCOS)

KW - preimplantation genetic testing (PGT)

UR - http://www.scopus.com/inward/record.url?scp=85081278504&partnerID=8YFLogxK

U2 - 10.3389/fendo.2020.00067

DO - 10.3389/fendo.2020.00067

M3 - Review

C2 - 32153506

AN - SCOPUS:85081278504

VL - 11

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 67

ER -