The functions Of LysM Proteins And Chitin Tetra-Saccarides Signaling Pathway in Zebrafish Embryos

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Fabrice Jean Francois Laroche, Danmark
Chitin is an ancient organic bio-polymer, found in abundance on land and at sea. However, knowledge on chitin functions in animals is lacking. In his research project, Fabrice Laroche studied responses to chitin in zebrafish embryos, and he described chitin signalling pathways.
Proteins related to chitin responses are increasingly being associated with human diseases. Recently, several lysin motif (LysM)-containing proteins were highlighted for their molecular affinity to chitin-like compounds. Addressing these matters, Fabrice Laroche identified zebrafish and human lysin motif-encoding genes and studied their roles – at the cellular level and during zebrafish development.
To improve the experimental methods, he developed nanotechnological strategies to genetically modify human embryonic kidney cells and zebrafish.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University, and the Department of Molecular Cell Biology, Leiden University, The Netherlands
OriginalsprogEngelsk
UdgivelsesstedAarhus University
ForlagAarhus University, Faculty of Science and Technology
Antal sider293
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 2012

Note vedr. afhandling

PhD defence held 5th April 2013

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