The Epidemiology of Pheochromocytoma: Is the Incidence Increasing?

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Background: Although pheochromocytoma is an exceedingly rare adrenal tumour, it is a frequent diagnostic dilemma due to its potential life-threatening nature. There is a widespread perception of an increase in incidence over the recent years, but no data on time trends exist.
Methods: Data were obtained from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma or catecholamine hypersecretion between 1/1/1977 and 31/12/2015. Health records were reviewed to validate the diagnosis for all patients in the Northern and Central Regions of Denmark. Incidence rates were calculated using Poisson regression and time trends were analysed with year as a continuous explanatory variable.
Results: We found an increasing trend from 2.06 (CI95% 1.68-2.49) per million person-years 1977-2006 to 4.65 (CI95% 3.72-5.82) 2007-2015. In addition, patients were older at diagnosis (p<0.001) and less symptomatic (p=0.032). No changes were observed in symptom duration, tumour size or level of catecholamines.
Conclusion: The incidence of pheochromocytoma has increased significantly in recent years, presumably due to the increased use of imaging studies leading to incidentally found adrenal tumours. These older incidentaloma patients appear to represent a new group of pheochromocytoma not previously diagnosed.
Udgivelsesår17 mar. 2017
StatusUdgivet - 17 mar. 2017
BegivenhedKongres for Medicinsk Studenterforskning 2017 - Hotel Sinatur Storebælt, Nyborg, Danmark
Varighed: 16 mar. 201719 mar. 2017


KonferenceKongres for Medicinsk Studenterforskning 2017
LokationHotel Sinatur Storebælt

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