The Epidemiology of Pheochromocytoma. Increasing Incidence and Changing Clinical Presentation. A population-based retrospective study 1977-2016

Publikation: KonferencebidragPosterForskning

Pheochromocytoma is a rare disease but frequently poses a diagnostic dilemma due to the unspecific symptoms and its potentially life-threatening nature. There is a perception of an increase in the incidence of pheochromocytomas in recent years, but no data on time trends exist.
We obtained data from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma in 1977-2016. Health records were reviewed to validate the diagnosis for all patients in the Northern and Central Regions of Denmark (population 1.75 million). Incidence rates were calculated using Poisson regression. 
We identified 198 confirmed cases of pheochromocytoma. A significant increasing trend (p<0.001) was observed in incidence rates from 2.17 (CI95% 1.79-2.62) per million person-years 1977-2006 to 4.67 (CI95% 3.73-5.76) 2007-2016. In 1977-2006 paroxysmal symptoms, autopsy and secondary hypertension were the primary causes leading to the diagnosis (33, 21 and 19 %, respectively), while incidentalomas were the leading cause of diagnosis 2007-2016 (55 %). Patients diagnosed 2007-2016 were also older (p<0.001) and less symptomatic (p=0.007) compared to 1977-2006.
The incidence of pheochromocytoma has increased significantly in recent years, presumably due to increased use of imaging studies. Incidentaloma patients appear to represent a new less symptomatic and older group of pheochromocytoma patients not previously diagnosed. Whether surgical treatment provides a health benefit in this group remains unknown.
OriginalsprogEngelsk
Udgivelsesår14 nov. 2017
StatusUdgivet - 14 nov. 2017
Begivenhed1st Annual Research Meeting at the Department of Clinical Medicine - Skejby Sygehus, Aarhus, Danmark
Varighed: 14 nov. 201714 nov. 2017

Seminar

Seminar1st Annual Research Meeting at the Department of Clinical Medicine
LokationSkejby Sygehus
LandDanmark
ByAarhus
Periode14/11/201714/11/2017

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