TY - JOUR
T1 - The effect of sodium hypochlorite and chlorhexidine as irrigant solutions for root canal disinfection
T2 - A systematic review of clinical trials
AU - Gonçalves, Lucio Souza
AU - Rodrigues, Renata Costa Val
AU - Andrade Junior, Carlos Vieira
AU - Soares, Renata G.
AU - Vettore, Mario Vianna
N1 - Publisher Copyright:
© 2016 American Association of Endodontists.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Introduction This systematic review aimed to compare the effectiveness of sodium hypochlorite and chlorhexidine for root canal disinfection during root canal therapy. Methods A literature search for clinical trials was made on the PubMed (MEDLINE), Web of Knowledge, SCOPUS, and Science Direct databases and in the reference lists of the identified articles up to January 2015. Quality assessment of the selected studies was performed according to the Consolidated Standards of Reporting Trials statement. Results One clinical trial and 4 randomized clinical trials were selected from the 172 articles initially identified. There was heterogeneity in the laboratory methods used to assess the root canal disinfection as well as in the concentrations of the irrigants used. Therefore, meta-analysis was not performed. Two studies reported effective and similar reductions in bacterial levels for both irrigants. Sodium hypochlorite was more effective than chlorhexidine in reducing microorganisms in 1 study, and another reported opposite findings. Both root irrigants were ineffective in eliminating endotoxins from necrotic pulp root canals in 1 study. Trial design and information regarding randomization procedures were not clearly described in the clinical trials. No study compared laboratory results with clinical outcomes. Conclusions The available evidence on this topic is scarce, and the findings of studies were not consistent. Additional randomized clinical trials using clinical outcomes to compare the use of sodium hypochlorite and chlorhexidine during root canal therapy are needed.
AB - Introduction This systematic review aimed to compare the effectiveness of sodium hypochlorite and chlorhexidine for root canal disinfection during root canal therapy. Methods A literature search for clinical trials was made on the PubMed (MEDLINE), Web of Knowledge, SCOPUS, and Science Direct databases and in the reference lists of the identified articles up to January 2015. Quality assessment of the selected studies was performed according to the Consolidated Standards of Reporting Trials statement. Results One clinical trial and 4 randomized clinical trials were selected from the 172 articles initially identified. There was heterogeneity in the laboratory methods used to assess the root canal disinfection as well as in the concentrations of the irrigants used. Therefore, meta-analysis was not performed. Two studies reported effective and similar reductions in bacterial levels for both irrigants. Sodium hypochlorite was more effective than chlorhexidine in reducing microorganisms in 1 study, and another reported opposite findings. Both root irrigants were ineffective in eliminating endotoxins from necrotic pulp root canals in 1 study. Trial design and information regarding randomization procedures were not clearly described in the clinical trials. No study compared laboratory results with clinical outcomes. Conclusions The available evidence on this topic is scarce, and the findings of studies were not consistent. Additional randomized clinical trials using clinical outcomes to compare the use of sodium hypochlorite and chlorhexidine during root canal therapy are needed.
KW - Chlorhexidine
KW - clinical trial
KW - endodontic
KW - sodium hypochlorite
UR - http://www.scopus.com/inward/record.url?scp=84957069927&partnerID=8YFLogxK
U2 - 10.1016/j.joen.2015.12.021
DO - 10.1016/j.joen.2015.12.021
M3 - Review
C2 - 26852149
AN - SCOPUS:84957069927
SN - 0099-2399
VL - 42
SP - 527
EP - 532
JO - Journal of Endodontics
JF - Journal of Endodontics
IS - 4
ER -