The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer: A systematic review

TY - JOUR

T1 - The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer

T2 - A systematic review

AU - Holm, Mette Overgaard

AU - Bye, Asta

AU - Falkmer, Ursula

AU - Tobberup, Randi

AU - Rasmussen, Henrik Højgaard

AU - Lauridsen, Charlotte

AU - Yilmaz, Mette Karen

AU - Søndergaard, Jimmi

AU - Poulsen, Laurids Østergaard

N1 - Publisher Copyright: © 2023 Elsevier B.V.

PY - 2023/8

Y1 - 2023/8

N2 - Acute radiation-induced diarrhoea (RID) is a well-known side effect of external radiation therapy for pelvic cancer. Acute RID is an unresolved clinical problem in approximately 80% of patients. We investigated the effect of nutritional interventions on acute RID in patients with pelvic cancer treated with curative radiotherapy. A search was conducted using PubMed, Embase.com, CINAHL, and Cochrane Library, from 1 January 2005 until 10 October 2022. We included randomised controlled trials or prospective observational studies. Eleven of the 21 identified studies had low quality of evidence, mainly because of low patient numbers distributed among several cancer diagnoses, and non-systematic assessment of acute RID. Interventions included probiotics (n = 6), prebiotics (n = 6), glutamine (n = 4), and others (n = 5). Five studies, of which two provided high quality evidence, showed that probiotics improved acute RID. Future well-designed studies investigating the effects of probiotics on acute RID are warranted. PROSPERO ID: CRD42020209499).

AB - Acute radiation-induced diarrhoea (RID) is a well-known side effect of external radiation therapy for pelvic cancer. Acute RID is an unresolved clinical problem in approximately 80% of patients. We investigated the effect of nutritional interventions on acute RID in patients with pelvic cancer treated with curative radiotherapy. A search was conducted using PubMed, Embase.com, CINAHL, and Cochrane Library, from 1 January 2005 until 10 October 2022. We included randomised controlled trials or prospective observational studies. Eleven of the 21 identified studies had low quality of evidence, mainly because of low patient numbers distributed among several cancer diagnoses, and non-systematic assessment of acute RID. Interventions included probiotics (n = 6), prebiotics (n = 6), glutamine (n = 4), and others (n = 5). Five studies, of which two provided high quality evidence, showed that probiotics improved acute RID. Future well-designed studies investigating the effects of probiotics on acute RID are warranted. PROSPERO ID: CRD42020209499).

KW - Bowel-related symptoms

KW - External radiotherapy

KW - GI toxicity

KW - Nutritional intervention

UR - http://www.scopus.com/inward/record.url?scp=85161636294&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2023.104038

DO - 10.1016/j.critrevonc.2023.104038

M3 - Review

C2 - 37236410

AN - SCOPUS:85161636294

SN - 1040-8428

VL - 188

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

M1 - 104038

ER -