The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Mandin-Darby canine kidney (MDCK) cells in ultrafiltered human urine

Lauren A. Thurgood, Esben Skipper Sørensen, Rosemary L. Ryall

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Abstract

Osteopontin has been shown to both promote and inhibit the attachment of calcium oxalate monohydrate crystals to cultured renal epithelial cells in aqueous media. In this study we examined the role of OPN on the growth and attachment of calcium oxalate dihydrate crystals, to which it more readily associates, to renal epithelial cells using urine as the binding medium. We showed that OPN inhibits the growth of COD crystals and that it reduces the binding of COD crystals to cells
OriginalsprogEngelsk
TidsskriftB J U International (Print)
Vol/bind109
Nummer7
Sider (fra-til)1100-1109
Antal sider10
ISSN1464-4096
DOI
StatusUdgivet - apr. 2012

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