The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Mandin-Darby canine kidney (MDCK) cells in ultrafiltered human urine

TY - JOUR

T1 - The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Mandin-Darby canine kidney (MDCK) cells in ultrafiltered human urine

AU - Thurgood, Lauren A.

AU - Sørensen, Esben Skipper

AU - Ryall, Rosemary L.

PY - 2012/4

Y1 - 2012/4

N2 - Osteopontin has been shown to both promote and inhibit the attachment of calcium oxalate monohydrate crystals to cultured renal epithelial cells in aqueous media. In this study we examined the role of OPN on the growth and attachment of calcium oxalate dihydrate crystals, to which it more readily associates, to renal epithelial cells using urine as the binding medium. We showed that OPN inhibits the growth of COD crystals and that it reduces the binding of COD crystals to cells

AB - Osteopontin has been shown to both promote and inhibit the attachment of calcium oxalate monohydrate crystals to cultured renal epithelial cells in aqueous media. In this study we examined the role of OPN on the growth and attachment of calcium oxalate dihydrate crystals, to which it more readily associates, to renal epithelial cells using urine as the binding medium. We showed that OPN inhibits the growth of COD crystals and that it reduces the binding of COD crystals to cells

U2 - 10.1111/j.1464-410X.2011.10530.x

DO - 10.1111/j.1464-410X.2011.10530.x

M3 - Journal article

C2 - 21883862

SN - 1464-4096

VL - 109

SP - 1100

EP - 1109

JO - B J U International (Print)

JF - B J U International (Print)

IS - 7

ER -