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The Eating Disorders Genetics Initiative (EDGI): study protocol

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DOI

  • Cynthia M Bulik, University of North Carolina at Chapel Hill, Karolinska Institutet
  • ,
  • Laura M Thornton, University of North Carolina at Chapel Hill
  • ,
  • Richard Parker, QIMR Berghofer Medical Research Institute
  • ,
  • Hannah Kennedy, Univ Otago, University of Otago, Relig Programme
  • ,
  • Jessica H Baker, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
  • ,
  • Casey MacDermod, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
  • ,
  • Jerry Guintivano, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
  • ,
  • Lana Cleland, Univ Otago, University of Otago, Relig Programme
  • ,
  • Allison L Miller, Univ Otago, University of Otago, Relig Programme
  • ,
  • Lauren Harper, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
  • ,
  • Janne T Larsen
  • Zeynep Yilmaz
  • Jakob Grove
  • Patrick F Sullivan, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron, Karolinska Institutet
  • ,
  • Liselotte V Petersen
  • Jennifer Jordan, Univ Otago, University of Otago, Relig Programme
  • ,
  • Martin A Kennedy, Univ Otago, University of Otago, Relig Programme
  • ,
  • Nicholas G Martin, QIMR Berghofer Medical Research Institute

BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.

METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).

DISCUSSION: EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.

TRIAL REGISTRATION: EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .

OriginalsprogEngelsk
Artikelnummer234
TidsskriftBMC Psychiatry
Vol/bind21
ISSN1471-244X
DOI
StatusUdgivet - maj 2021

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