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The EADGENE Microarray Data Analysis Workshop

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  • GSE 39

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  • Dirk-Jan de Koning, Institute for Animal Health, Perbright, Storbritannien
  • Florence Jaffrézic, INRA, UR337, Frankrig
  • Mogens Sandø Lund
  • Michael Watson, Roslin Institute, Storbritannien
  • Caroline Channing, Roslin Institute, Storbritannien
  • Ina Hulsegge, Animal Breeding and Genomics Centre, ABGC, Holland
  • Marco Pool, Animal Breeding and Genomics Centre, ABGC, Holland
  • Bart Buitenhuis
  • Jakob Hedegaard, Danmark
  • Henrik Hornshøj, Danmark
  • Li Jiang, Danmark
  • Peter Sørensen
  • Guillemette Marot, INRA, Frankrig
  • Céline Delmas, INRA, Frankrig
  • Kim-Anh Lê Cao, INRA, Frankrig
  • Magali SanChristobal, INRA, Frankrig
  • Michael D Baron, Institute for Animal Health, Pirbright, Storbritannien
  • Roberto Malinverni, Parco Tecnologico Padano, PTP, Italien
  • Alessandra Stella, Parco Tecnologico Padano, PTP, Italien
  • Ronald Brunner, Research Institute for the Biology of Farm Animals, Dummerstorf, Tyskland
  • Hans-Martin Seyfert, Research Institute for the Biology of Farm Animals, Dummerstorf, Tyskland
  • Kirsty Jensen, Roslin Institute, Storbritannien
  • Daphne Mouzaki, Roslin Institute, Storbritannien
  • Dave Waddington, Roslin Institute, Storbritannien
  • Angeles Jiménez-Martin, University of Córdoba, Spanien
  • Mònica Pèrez Alegre, University of Córdoba, Spanien
  • Eva Pérez, University of Córdoba, Spanien
  • Rodrigue Closset, University of Liege, Belgien
  • Johanne Detilleux, University of Liege, Belgien
  • Peter Dovc, University of Ljubljana, Slovenien
  • Miha Lavric, University of Ljubljana, Slovenien
  • Luc Janss
  • Institut for Genetik og Bioteknologi
  • Biostatistik
  • Molekylær Genetik og Systembiologi
Microarray analyses have become an important tool in animal genomics. While their use is becoming widespread, there is still a lot of ongoing research regarding the analysis of microarray data. In the context of a European Network of Excellence, 31 researchers representing 14 research groups from 10 countries performed and discussed the statistical analyses of real and simulated 2-colour microarray data that were distributed among participants. The real data consisted of 48 microarrays from a disease challenge experiment in dairy cattle, while the simulated data consisted of 10 microarrays from a direct comparison of two treatments (dye-balanced). While there was broader agreement with regards to methods of microarray normalisation and significance testing, there were major differences with regards to quality control. The quality control approaches varied from none, through using statistical weights, to omitting a large number of spots or omitting entire slides. Surprisingly, these very different approaches gave quite similar results when applied to the simulated data, although not all participating groups analysed both real and simulated data. The workshop was very successful in facilitating interaction between scientists with a diverse background but a common interest in microarray analyses
TidsskriftGenetics Selection Evolution
Sider (fra-til)621-631
Antal sider11
StatusUdgivet - 2007

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