The dental perspective on osteogenesis imperfecta in a Danish adult population

Kirstine Juhl Thuesen; Hans Gjørup; Jannie Dahl Hald; Malene Hørnø Schmidt; Torben Harsløf; Bente Lomholt Langdahl; Dorte Haubek

doi:10.1186/s12903-018-0639-7

The dental perspective on osteogenesis imperfecta in a Danish adult population

Kirstine Juhl Thuesen, Hans Gjørup, Jannie Dahl Hald, Malene Hørnø Schmidt, Torben Harsløf, Bente Lomholt Langdahl, Dorte Haubek

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

Background: To report on dental characteristics and treatment load in Danish adult patients with osteogenesis imperfecta (OI). Methods: Oral examination of 73 patients with OI was performed and OI type I, III, and IV were represented by 75.3%, 8.2%, and 16.4%, respectively. Patients were diagnosed as having dentinogenesis imperfecta (DI) if they had clinical and radiological signs of DI. In the data analysis, mild OI (type I) was compared to moderate-severe OI (type III and IV). Results: Discoloration of teeth was prevalent in patients with moderate-severe compared to mild OI (83.3% vs. 5.5%, p<0.001). Cervical constriction and pulpal obliteration were frequent findings in patients with moderate-severe OI (61.1% and 88.9%, respectively), whereas pulp stones and taurodontism were diagnosed in patients with mild OI only (29.1% and 9.1%, respectively). DI was found in 24.7% of OI patients and considerably more frequent in patients with moderate-severe (94.4%) compared to mild OI (1.8%) (p<0.001). The number of teeth with artificial crowns was significantly higher in patients with moderate-severe OI than in patients with mild OI (median 1.5, range 0-23 vs. median 0, range 0-14) (p<0.001). The number of teeth with fillings in patients with mild OI was significantly higher than in patients with moderate-severe OI (mean 9.7, SD 5.1, median 9.0, range 1-21 vs. mean 5.0, SD 4.4, median 4.0, range 0-16) (p<0.001). Conclusions: One fourth of patients with OI had DI, and the vast majority of them had moderate-severe OI. Whereas discoloration of teeth, cervical constriction and pulp obliteration were frequent findings in patients with moderate-severe OI, pulp stones and taurodontism were found in patients with mild OI only. In patients with moderate-severe OI, the dental treatment load was dominated by prosthetic treatment, whereas restorative treatment with fillings was more prevalent in patients with mild OI.

Originalsprog	Engelsk
Artikelnummer	175
Tidsskrift	BMC Oral Health
Vol/bind	18
Nummer	1
Sider (fra-til)	1-7
Antal sider	7
ISSN	1472-6831
DOI	https://doi.org/10.1186/s12903-018-0639-7
Status	Udgivet - 24 okt. 2018

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10.1186/s12903-018-0639-7

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title = "The dental perspective on osteogenesis imperfecta in a Danish adult population",

abstract = "Background: To report on dental characteristics and treatment load in Danish adult patients with osteogenesis imperfecta (OI). Methods: Oral examination of 73 patients with OI was performed and OI type I, III, and IV were represented by 75.3%, 8.2%, and 16.4%, respectively. Patients were diagnosed as having dentinogenesis imperfecta (DI) if they had clinical and radiological signs of DI. In the data analysis, mild OI (type I) was compared to moderate-severe OI (type III and IV). Results: Discoloration of teeth was prevalent in patients with moderate-severe compared to mild OI (83.3% vs. 5.5%, p<0.001). Cervical constriction and pulpal obliteration were frequent findings in patients with moderate-severe OI (61.1% and 88.9%, respectively), whereas pulp stones and taurodontism were diagnosed in patients with mild OI only (29.1% and 9.1%, respectively). DI was found in 24.7% of OI patients and considerably more frequent in patients with moderate-severe (94.4%) compared to mild OI (1.8%) (p<0.001). The number of teeth with artificial crowns was significantly higher in patients with moderate-severe OI than in patients with mild OI (median 1.5, range 0-23 vs. median 0, range 0-14) (p<0.001). The number of teeth with fillings in patients with mild OI was significantly higher than in patients with moderate-severe OI (mean 9.7, SD 5.1, median 9.0, range 1-21 vs. mean 5.0, SD 4.4, median 4.0, range 0-16) (p<0.001). Conclusions: One fourth of patients with OI had DI, and the vast majority of them had moderate-severe OI. Whereas discoloration of teeth, cervical constriction and pulp obliteration were frequent findings in patients with moderate-severe OI, pulp stones and taurodontism were found in patients with mild OI only. In patients with moderate-severe OI, the dental treatment load was dominated by prosthetic treatment, whereas restorative treatment with fillings was more prevalent in patients with mild OI.",

keywords = "Collagen, Dental treatment load, Dentinogenesis imperfecta, Radiographic findings",

author = "Thuesen, {Kirstine Juhl} and Hans Gj{\o}rup and Hald, {Jannie Dahl} and Schmidt, {Malene H{\o}rn{\o}} and Torben Harsl{\o}f and Langdahl, {Bente Lomholt} and Dorte Haubek",

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T1 - The dental perspective on osteogenesis imperfecta in a Danish adult population

AU - Thuesen, Kirstine Juhl

AU - Gjørup, Hans

AU - Hald, Jannie Dahl

AU - Schmidt, Malene Hørnø

AU - Harsløf, Torben

AU - Langdahl, Bente Lomholt

AU - Haubek, Dorte

PY - 2018/10/24

Y1 - 2018/10/24

N2 - Background: To report on dental characteristics and treatment load in Danish adult patients with osteogenesis imperfecta (OI). Methods: Oral examination of 73 patients with OI was performed and OI type I, III, and IV were represented by 75.3%, 8.2%, and 16.4%, respectively. Patients were diagnosed as having dentinogenesis imperfecta (DI) if they had clinical and radiological signs of DI. In the data analysis, mild OI (type I) was compared to moderate-severe OI (type III and IV). Results: Discoloration of teeth was prevalent in patients with moderate-severe compared to mild OI (83.3% vs. 5.5%, p<0.001). Cervical constriction and pulpal obliteration were frequent findings in patients with moderate-severe OI (61.1% and 88.9%, respectively), whereas pulp stones and taurodontism were diagnosed in patients with mild OI only (29.1% and 9.1%, respectively). DI was found in 24.7% of OI patients and considerably more frequent in patients with moderate-severe (94.4%) compared to mild OI (1.8%) (p<0.001). The number of teeth with artificial crowns was significantly higher in patients with moderate-severe OI than in patients with mild OI (median 1.5, range 0-23 vs. median 0, range 0-14) (p<0.001). The number of teeth with fillings in patients with mild OI was significantly higher than in patients with moderate-severe OI (mean 9.7, SD 5.1, median 9.0, range 1-21 vs. mean 5.0, SD 4.4, median 4.0, range 0-16) (p<0.001). Conclusions: One fourth of patients with OI had DI, and the vast majority of them had moderate-severe OI. Whereas discoloration of teeth, cervical constriction and pulp obliteration were frequent findings in patients with moderate-severe OI, pulp stones and taurodontism were found in patients with mild OI only. In patients with moderate-severe OI, the dental treatment load was dominated by prosthetic treatment, whereas restorative treatment with fillings was more prevalent in patients with mild OI.

AB - Background: To report on dental characteristics and treatment load in Danish adult patients with osteogenesis imperfecta (OI). Methods: Oral examination of 73 patients with OI was performed and OI type I, III, and IV were represented by 75.3%, 8.2%, and 16.4%, respectively. Patients were diagnosed as having dentinogenesis imperfecta (DI) if they had clinical and radiological signs of DI. In the data analysis, mild OI (type I) was compared to moderate-severe OI (type III and IV). Results: Discoloration of teeth was prevalent in patients with moderate-severe compared to mild OI (83.3% vs. 5.5%, p<0.001). Cervical constriction and pulpal obliteration were frequent findings in patients with moderate-severe OI (61.1% and 88.9%, respectively), whereas pulp stones and taurodontism were diagnosed in patients with mild OI only (29.1% and 9.1%, respectively). DI was found in 24.7% of OI patients and considerably more frequent in patients with moderate-severe (94.4%) compared to mild OI (1.8%) (p<0.001). The number of teeth with artificial crowns was significantly higher in patients with moderate-severe OI than in patients with mild OI (median 1.5, range 0-23 vs. median 0, range 0-14) (p<0.001). The number of teeth with fillings in patients with mild OI was significantly higher than in patients with moderate-severe OI (mean 9.7, SD 5.1, median 9.0, range 1-21 vs. mean 5.0, SD 4.4, median 4.0, range 0-16) (p<0.001). Conclusions: One fourth of patients with OI had DI, and the vast majority of them had moderate-severe OI. Whereas discoloration of teeth, cervical constriction and pulp obliteration were frequent findings in patients with moderate-severe OI, pulp stones and taurodontism were found in patients with mild OI only. In patients with moderate-severe OI, the dental treatment load was dominated by prosthetic treatment, whereas restorative treatment with fillings was more prevalent in patients with mild OI.

KW - Collagen

KW - Dental treatment load

KW - Dentinogenesis imperfecta

KW - Radiographic findings

U2 - 10.1186/s12903-018-0639-7

DO - 10.1186/s12903-018-0639-7

M3 - Journal article

C2 - 30355314

SN - 1472-6831

VL - 18

SP - 1

EP - 7

JO - BMC Oral Health

JF - BMC Oral Health

IS - 1

M1 - 175

ER -

The dental perspective on osteogenesis imperfecta in a Danish adult population

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