The Crystal Structure of Human α(2) -Macroglobulin Reveals a Unique Molecular Cage

Aniebrys Marrero, Stephane Duquerroy, Stefano Trapani, Theodoros Goulas, Tibisay Guevara, Gregers Rom Andersen, Jorge Navaza, Lars Sottrup-Jensen, F Xavier Gomis-Rüth

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Abstract

I'm your Venus: The crystal structure of the human methylamine-induced form of α(2) -macroglobulin (α(2) M) shows its large central cavity can accommodate two medium-sized proteinases (see structure, front part clipped off to better show central cavity). Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2) M.
OriginalsprogEngelsk
TidsskriftAngewandte Chemie International Edition
Vol/bind51
Nummer14
Sider (fra-til)3340-44
ISSN1433-7851
DOI
StatusUdgivet - 2012

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