TY - JOUR
T1 - The biogenesis, biology and characterization of circular RNAs
AU - Kristensen, Lasse Sommer
AU - Schertz Andersen, Maria
AU - Stagsted, Lotte Victoria Winther
AU - Ebbesen, Karoline
AU - Hansen, Thomas Birkballe
AU - Kjems, Jørgen
PY - 2019/11
Y1 - 2019/11
N2 - Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis-acting elements and trans-acting factors. Some circRNAs are abundant and evolutionarily conserved, and many circRNAs exert important biological functions by acting as microRNA or protein inhibitors (‘sponges’), by regulating protein function or by being translated themselves. Furthermore, circRNAs have been implicated in diseases such as diabetes mellitus, neurological disorders, cardiovascular diseases and cancer. Although the circular nature of these transcripts makes their detection, quantification and functional characterization challenging, recent advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
AB - Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis-acting elements and trans-acting factors. Some circRNAs are abundant and evolutionarily conserved, and many circRNAs exert important biological functions by acting as microRNA or protein inhibitors (‘sponges’), by regulating protein function or by being translated themselves. Furthermore, circRNAs have been implicated in diseases such as diabetes mellitus, neurological disorders, cardiovascular diseases and cancer. Although the circular nature of these transcripts makes their detection, quantification and functional characterization challenging, recent advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
UR - https://www.scopus.com/pages/publications/85070791281
U2 - 10.1038/s41576-019-0158-7
DO - 10.1038/s41576-019-0158-7
M3 - Review
C2 - 31395983
SN - 1471-0056
VL - 20
SP - 675
EP - 691
JO - Nature Reviews. Genetics
JF - Nature Reviews. Genetics
IS - 11
ER -