The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies

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  • Eleanor L Watts, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Aurora Perez-Cornago, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Paul N Appleby, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Demetrius Albanes, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • Eva Ardanaz, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Spanien
  • Amanda Black, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • H Bas Bueno-de-Mesquita, Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Department of Epidemiology and Biostatistics, the School of Public Health, Imperial College London, United Kingdom. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, the Netherlands. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Malaysia
  • June M Chan, University of California, USA
  • Chu Chen, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA., USA
  • S A Paul Chubb, Fiona Stanley Hospital, University of Western Australia, Australien
  • Michael B Cook, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • Mélanie Deschasaux, Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France., Frankrig
  • Jenny L Donovan, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Storbritannien
  • Dallas R English, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia., Cancer Council Victoria, Australien
  • Leon Flicker, Department of Geriatric Medicine, Royal Perth Hospital, Perth, Australia., University of Western Australia, Harry Perkins Institute of Medical Research, Australien
  • Neal D Freedman, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • Pilar Galan, Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France., Frankrig
  • Graham G Giles, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia., Cancer Council Victoria, Australien
  • Edward L Giovannucci, Harvard T.H. Chan School of Public Health, Boston, MA, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
  • Marc J Gunter, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France., Frankrig
  • Laurel A Habel, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA, USA
  • Christel Häggström, Department of Biobank Research, Umeå University, Umeå, Sweden., Sverige
  • Christopher Haiman, University of Southern California, USA
  • Freddie C Hamdy, Nuffield Department of Surgery, University of Oxford, Oxford, UK., Storbritannien
  • Serge Hercberg, Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France., Frankrig
  • Jeff M Holly, IGFs & Metabolic Endocrinology Group, Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK., Storbritannien
  • Jiaqi Huang, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • Wen-Yi Huang, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • Mattias Johansson, Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France., Frankrig
  • Rudolf Kaaks, Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany., Tyskland
  • Tatsuhiko Kubo, Department of Environmental Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan., Japan
  • J Athene Lane, National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Bristol, UK., University of Bristol, Storbritannien
  • Tracy M Layne, Icahn School of Medicine at Mount Sinai, USA
  • Loic Le Marchand, University of Hawaii Cancer Center, Honolulu, HI, USA., USA
  • Richard M Martin, University of Bristol, National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Bristol, UK., Storbritannien
  • E Jeffrey Metter, Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA., USA
  • Kazuya Mikami, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan., Japan
  • Roger L Milne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia., Cancer Council Victoria, Australien
  • Howard A Morris, Chemical Pathology Directorate, SA Pathology, Adelaide, Australia., Australien
  • Lorelei A Mucci, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • David E Neal, Nuffield Department of Surgery, University of Oxford, Oxford, UK., Storbritannien
  • Marian L Neuhouser, Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., USA
  • Steven E Oliver, Department of Health Sciences, University of York and the Hull York Medical School, York, UK., Storbritannien
  • Kim Overvad
  • Kotaro Ozasa, Radiation Effects Research Foundation, Hiroshima, Japan., Japan
  • Valeria Pala, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Italien
  • Claire H Pernar, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., USA
  • Michael Pollak, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada., McGill University, Canada
  • Mari-Anne Rowlands, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Storbritannien
  • Catherine A Schaefer, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA, USA
  • Jeannette M Schenk, Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., USA
  • Pär Stattin, Hedenstierna Laboratory Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Sverige
  • Akiko Tamakoshi, Hokkaido University, Japan
  • Elin Thysell, Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden., Sverige
  • Mathilde Touvier, Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France., Frankrig
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece, Grækenland
  • Konstantinos K Tsilidis, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Imperial College London, Grækenland
  • Stephen K Van Den Eeden, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA, USA
  • Stephanie J Weinstein, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA., USA
  • Lynne Wilkens, University of Hawaii Cancer Center, Honolulu, HI, USA., USA
  • Bu B Yeap, Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Australia., University of Western Australia, Australien
  • Timothy J Key, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Naomi E Allen, Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK., Storbritannien
  • Ruth C Travis, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22–89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind145
Nummer12
Sider (fra-til)3244-3256
Antal sider13
ISSN0020-7136
DOI
StatusUdgivet - dec. 2019

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