The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile: development of a general synthetic strategy

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We demonstrate that a unique class-defining functionality (mc-APD) found in macrocyclic natural products with potent anti-cancer activity, imparts these compounds with electrophilic reactivity. The mc-APD group represents an interesting structural hybrid between canonical biologically relevant Michael-acceptors. Further, a novel thiol-elimination method for preparation of the mc-APD group is outlined.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind51
Nummer62
Sider (fra-til)12427-12430
Antal sider4
ISSN1359-7345
DOI
StatusUdgivet - 21 jul. 2015

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