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The Absorption Profile of Pregabalin in Chronic Pancreatitis

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  • Anne Estrup Olesen, Danmark
  • Erik Olofsen
  • ,
  • Søren Schou Olesen, Danmark
  • Camilla Staahl, Danmark
  • Trine Andresen, Danmark
  • Albert Dahan
  • ,
  • Asbjørn Mohr Drewes
It was recently shown that pregabalin decreased pain associated with chronic pancreatitis. It is well known that pancreatitis patients suffer from fat malabsorption with accompanying diarrhoea due to loss of exocrine pancreatic enzyme production. This may lead to changes in the mucosal surface in the small intestine and possibly affect the absorption of pregabalin. The pharmacokinetics of pregabalin has never been investigated in patients suffering from chronic pancreatitis. The aim of this study was to develop a population pharmacokinetic model of pregabalin administered to patients with chronic pancreatitis. The pregabalin population pharmacokinetic analysis was conducted on data from fifteen patients with chronic pancreatitis. Each patient received 75 mg of pregabalin (oral capsule). Pregabalin concentrations were measured using a validated liquid chromatographic method. Data analysis was performed using non-linear mixed effects modeling methodology as implemented by NONMEM. A one compartment model with first-order absorption and elimination adequately described pregabalin pharmacokinetics. Time to maximum observed plasma concentration (T(max) ) was 1.53 (95%CI 1.09-2.05). The maximum plasma concentration (C(max) ) was 1.98 μg/ml (95%CI 1.69-2.34) and area under the plasma concentration-time profile (AUC) was 18.2 μg*h/ml (95%CI 14.7-26.3). Pregabalin is well absorbed in patients with chronic pancreatitis and the pharmacokinetic profile of pregabalin is not extensively affected by chronic pancreatitis.
OriginalsprogEngelsk
TidsskriftBasic & Clinical Pharmacology & Toxicology
Vol/bind111
Nummer6
Sider (fra-til)385-390
Antal sider6
ISSN1742-7835
DOI
StatusUdgivet - 2012

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