Aarhus University Seal / Aarhus Universitets segl

Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Malene Roland Pedersen
  • ,
  • Catherine Horsfield
  • ,
  • Oliver Foot
  • ,
  • Jan Lindebjerg
  • ,
  • Palle Jørn Sloth Osther
  • ,
  • Peter Vedsted
  • Ashish Chandra
  • ,
  • Søren Rafael Rafaelsen
  • ,
  • Henrik Møller

INTRODUCTION: Testicular cancer is the most common type of cancer in young Caucasian men. It has been suggested that testicular microlithiasis (TML) is a premalignant condition. This study's objective was to investigate TML histology prevalence in testicular cancer patients in two European populations.

METHODS: We analysed archived histopathology orchiectomy specimens from 152 patients diagnosed with testicular cancer at Fredericia Hospital in Denmark from 2004 to 2014, and 106 patients diagnosed at St Thomas' Hospital in London from 2011 to 2015.

RESULTS: The Danish patients' median age was 37 years (range: 16-74 years) and the English patients' 36 years (range: 18-78 years). In the Danish patients, 29 (19.1%) had TML, and in the English patients, 43 (40.6%) had TML (p < 0.001). Haematoxylin bodies were slightly more common in the English patients. Laminated calcification was more often seen in seminomas than in non-seminomas.
 CONCLUSIONS: The English testicular cancer patients had a statistically significantly higher TML prevalence than the Danish patients. This observation questions the hypothesised biological association between TML and testicular 

FUNDING: The Region of Southern Denmark supported this study.


TidsskriftDanish Medical Journal
StatusUdgivet - mar. 2018

Se relationer på Aarhus Universitet Citationsformater

ID: 123440370