Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation

John Joseph Coughlan; Michael Maeng; Lorenz Räber; Salvatore Brugaletta; Alp Aytekin; Lisette Okkels Jensen; Sarah Bär; Luis Ortega-Paz; Karl-Ludwig Laugwitz; Morten Madsen; Dik Heg; Manel Sabaté; Sebastian Kufner; Kevin Kris Warnakula Olesen; Adnan Kastrati; Stephan Windecker; Salvatore Cassese

doi:10.1016/j.rec.2022.02.003

Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation

Bidragets oversatte titel: Trombosis del stent 10 años después de la intervención coronaria percutánea con stents nuevos frente a stents de la primera generación: Observaciones del metanálisis DECADE

John Joseph Coughlan, Michael Maeng, Lorenz Räber, Salvatore Brugaletta, Alp Aytekin, Lisette Okkels Jensen, Sarah Bär, Luis Ortega-Paz, Karl-Ludwig Laugwitz, Morten Madsen, Dik Heg, Manel Sabaté, Sebastian Kufner, Kevin Kris Warnakula Olesen, Adnan Kastrati, Stephan Windecker, Salvatore Cassese^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

INTRODUCTION AND OBJECTIVES: The DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES.

METHODS: Individual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach.

RESULTS: We included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI.

CONCLUSIONS: The incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.

Bidragets oversatte titel	Trombosis del stent 10 años después de la intervención coronaria percutánea con stents nuevos frente a stents de la primera generación: Observaciones del metanálisis DECADE
Originalsprog	Engelsk
Tidsskrift	Revista española de cardiología (English ed.)
Vol/bind	75
Nummer	11
Sider (fra-til)	894-902
Antal sider	9
DOI	https://doi.org/10.1016/j.rec.2022.02.003
Status	Udgivet - nov. 2022

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10.1016/j.rec.2022.02.003

Citationsformater

Coughlan, J. J., Maeng, M., Räber, L., Brugaletta, S., Aytekin, A., Okkels Jensen, L., Bär, S., Ortega-Paz, L., Laugwitz, K.-L., Madsen, M., Heg, D., Sabaté, M., Kufner, S., Warnakula Olesen, K. K., Kastrati, A., Windecker, S., & Cassese, S. (2022). Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation. Revista española de cardiología (English ed.), 75(11), 894-902. https://doi.org/10.1016/j.rec.2022.02.003

@article{1e7a314c06494dc4897adc061155bbf6,

title = "Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation",

abstract = "INTRODUCTION AND OBJECTIVES: The DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES.METHODS: Individual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach.RESULTS: We included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI.CONCLUSIONS: The incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.",

author = "Coughlan, {John Joseph} and Michael Maeng and Lorenz R{\"a}ber and Salvatore Brugaletta and Alp Aytekin and {Okkels Jensen}, Lisette and Sarah B{\"a}r and Luis Ortega-Paz and Karl-Ludwig Laugwitz and Morten Madsen and Dik Heg and Manel Sabat{\'e} and Sebastian Kufner and {Warnakula Olesen}, {Kevin Kris} and Adnan Kastrati and Stephan Windecker and Salvatore Cassese",

year = "2022",

month = nov,

doi = "10.1016/j.rec.2022.02.003",

language = "English",

volume = "75",

pages = "894--902",

journal = "Revista espa{\~n}ola de cardiolog{\'i}a (English ed.)",

issn = "1885-5857",

publisher = "Ediciones Doyma, S.L.",

number = "11",

}

Coughlan, JJ, Maeng, M, Räber, L, Brugaletta, S, Aytekin, A, Okkels Jensen, L, Bär, S, Ortega-Paz, L, Laugwitz, K-L, Madsen, M, Heg, D, Sabaté, M, Kufner, S, Warnakula Olesen, KK, Kastrati, A, Windecker, S & Cassese, S 2022, 'Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation', Revista española de cardiología (English ed.), bind 75, nr. 11, s. 894-902. https://doi.org/10.1016/j.rec.2022.02.003

Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation. / Coughlan, John Joseph; Maeng, Michael; Räber, Lorenz et al.
I: Revista española de cardiología (English ed.), Bind 75, Nr. 11, 11.2022, s. 894-902.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents

T2 - insights from the DECADE cooperation

AU - Coughlan, John Joseph

AU - Maeng, Michael

AU - Räber, Lorenz

AU - Brugaletta, Salvatore

AU - Aytekin, Alp

AU - Okkels Jensen, Lisette

AU - Bär, Sarah

AU - Ortega-Paz, Luis

AU - Laugwitz, Karl-Ludwig

AU - Madsen, Morten

AU - Heg, Dik

AU - Sabaté, Manel

AU - Kufner, Sebastian

AU - Warnakula Olesen, Kevin Kris

AU - Kastrati, Adnan

AU - Windecker, Stephan

AU - Cassese, Salvatore

PY - 2022/11

Y1 - 2022/11

N2 - INTRODUCTION AND OBJECTIVES: The DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES.METHODS: Individual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach.RESULTS: We included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI.CONCLUSIONS: The incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.

AB - INTRODUCTION AND OBJECTIVES: The DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES.METHODS: Individual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach.RESULTS: We included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI.CONCLUSIONS: The incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.

U2 - 10.1016/j.rec.2022.02.003

DO - 10.1016/j.rec.2022.02.003

M3 - Journal article

C2 - 35437213

SN - 1885-5857

VL - 75

SP - 894

EP - 902

JO - Revista española de cardiología (English ed.)

JF - Revista española de cardiología (English ed.)

IS - 11

ER -

Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation

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