Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents

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Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016 : results from 13 countries in three continents. / Cherubini, Valentino; Grimsmann, Julia M.; Åkesson, Karin; Birkebæk, Niels H.; Cinek, Ondrej; Dovč, Klemen; Gesuita, Rosaria; Gregory, John W.; Hanas, Ragnar; Hofer, Sabine E.; Holl, Reinhard W.; Jefferies, Craig; Joner, Geir; King, Bruce R.; Mayer-Davis, Elizabeth J.; Peña, Alexia S.; Rami-Merhar, Birgit; Schierloh, Ulrike; Skrivarhaug, Torild; Sumnik, Zdenek; Svensson, Jannet; Warner, Justin T.; Bratina, Nataša; Dabelea, Dana.

I: Diabetologia, Bind 63, Nr. 8, 08.2020, s. 1530-1541.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Cherubini, V, Grimsmann, JM, Åkesson, K, Birkebæk, NH, Cinek, O, Dovč, K, Gesuita, R, Gregory, JW, Hanas, R, Hofer, SE, Holl, RW, Jefferies, C, Joner, G, King, BR, Mayer-Davis, EJ, Peña, AS, Rami-Merhar, B, Schierloh, U, Skrivarhaug, T, Sumnik, Z, Svensson, J, Warner, JT, Bratina, N & Dabelea, D 2020, 'Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents', Diabetologia, bind 63, nr. 8, s. 1530-1541. https://doi.org/10.1007/s00125-020-05152-1

APA

Cherubini, V., Grimsmann, J. M., Åkesson, K., Birkebæk, N. H., Cinek, O., Dovč, K., Gesuita, R., Gregory, J. W., Hanas, R., Hofer, S. E., Holl, R. W., Jefferies, C., Joner, G., King, B. R., Mayer-Davis, E. J., Peña, A. S., Rami-Merhar, B., Schierloh, U., Skrivarhaug, T., ... Dabelea, D. (2020). Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents. Diabetologia, 63(8), 1530-1541. https://doi.org/10.1007/s00125-020-05152-1

CBE

Cherubini V, Grimsmann JM, Åkesson K, Birkebæk NH, Cinek O, Dovč K, Gesuita R, Gregory JW, Hanas R, Hofer SE, Holl RW, Jefferies C, Joner G, King BR, Mayer-Davis EJ, Peña AS, Rami-Merhar B, Schierloh U, Skrivarhaug T, Sumnik Z, Svensson J, Warner JT, Bratina N, Dabelea D. 2020. Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents. Diabetologia. 63(8):1530-1541. https://doi.org/10.1007/s00125-020-05152-1

MLA

Vancouver

Author

Cherubini, Valentino ; Grimsmann, Julia M. ; Åkesson, Karin ; Birkebæk, Niels H. ; Cinek, Ondrej ; Dovč, Klemen ; Gesuita, Rosaria ; Gregory, John W. ; Hanas, Ragnar ; Hofer, Sabine E. ; Holl, Reinhard W. ; Jefferies, Craig ; Joner, Geir ; King, Bruce R. ; Mayer-Davis, Elizabeth J. ; Peña, Alexia S. ; Rami-Merhar, Birgit ; Schierloh, Ulrike ; Skrivarhaug, Torild ; Sumnik, Zdenek ; Svensson, Jannet ; Warner, Justin T. ; Bratina, Nataša ; Dabelea, Dana. / Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016 : results from 13 countries in three continents. I: Diabetologia. 2020 ; Bind 63, Nr. 8. s. 1530-1541.

Bibtex

@article{27c2dbfff8d9406e9b37bd3f0af9bec4,
title = "Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents",
abstract = "Aims/hypothesis: The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents. Methods: An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Mean prevalence was estimated for the entire period, both overall and by country, adjusted for sex and age group. Temporal trends in annual prevalence of DKA were estimated using logistic regression analysis for each country, before and after adjustment for sex, age group and ethnic minority status. Results: During the study period, new-onset type 1 diabetes was diagnosed in 59,000 children (median age [interquartile range], 9.0 years [5.5–11.7]; male sex, 52.9%). The overall adjusted DKA prevalence was 29.9%, with the lowest prevalence in Sweden and Denmark and the highest in Luxembourg and Italy. The adjusted DKA prevalence significantly increased over time in Australia, Germany and the USA while it decreased in Italy. Preschool children, adolescents and children from ethnic minority groups were at highest risk of DKA at diabetes diagnosis in most countries. A significantly higher risk was also found for females in Denmark, Germany and Slovenia. Conclusions/interpretation: DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups.",
keywords = "Children with diabetes, Complications, Diabetic ketoacidosis, Diagnosis of diabetes, Epidemiology, Type 1 diabetes",
author = "Valentino Cherubini and Grimsmann, {Julia M.} and Karin {\AA}kesson and Birkeb{\ae}k, {Niels H.} and Ondrej Cinek and Klemen Dov{\v c} and Rosaria Gesuita and Gregory, {John W.} and Ragnar Hanas and Hofer, {Sabine E.} and Holl, {Reinhard W.} and Craig Jefferies and Geir Joner and King, {Bruce R.} and Mayer-Davis, {Elizabeth J.} and Pe{\~n}a, {Alexia S.} and Birgit Rami-Merhar and Ulrike Schierloh and Torild Skrivarhaug and Zdenek Sumnik and Jannet Svensson and Warner, {Justin T.} and Nata{\v s}a Bratina and Dana Dabelea",
year = "2020",
month = aug,
doi = "10.1007/s00125-020-05152-1",
language = "English",
volume = "63",
pages = "1530--1541",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016

T2 - results from 13 countries in three continents

AU - Cherubini, Valentino

AU - Grimsmann, Julia M.

AU - Åkesson, Karin

AU - Birkebæk, Niels H.

AU - Cinek, Ondrej

AU - Dovč, Klemen

AU - Gesuita, Rosaria

AU - Gregory, John W.

AU - Hanas, Ragnar

AU - Hofer, Sabine E.

AU - Holl, Reinhard W.

AU - Jefferies, Craig

AU - Joner, Geir

AU - King, Bruce R.

AU - Mayer-Davis, Elizabeth J.

AU - Peña, Alexia S.

AU - Rami-Merhar, Birgit

AU - Schierloh, Ulrike

AU - Skrivarhaug, Torild

AU - Sumnik, Zdenek

AU - Svensson, Jannet

AU - Warner, Justin T.

AU - Bratina, Nataša

AU - Dabelea, Dana

PY - 2020/8

Y1 - 2020/8

N2 - Aims/hypothesis: The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents. Methods: An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Mean prevalence was estimated for the entire period, both overall and by country, adjusted for sex and age group. Temporal trends in annual prevalence of DKA were estimated using logistic regression analysis for each country, before and after adjustment for sex, age group and ethnic minority status. Results: During the study period, new-onset type 1 diabetes was diagnosed in 59,000 children (median age [interquartile range], 9.0 years [5.5–11.7]; male sex, 52.9%). The overall adjusted DKA prevalence was 29.9%, with the lowest prevalence in Sweden and Denmark and the highest in Luxembourg and Italy. The adjusted DKA prevalence significantly increased over time in Australia, Germany and the USA while it decreased in Italy. Preschool children, adolescents and children from ethnic minority groups were at highest risk of DKA at diabetes diagnosis in most countries. A significantly higher risk was also found for females in Denmark, Germany and Slovenia. Conclusions/interpretation: DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups.

AB - Aims/hypothesis: The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents. Methods: An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Mean prevalence was estimated for the entire period, both overall and by country, adjusted for sex and age group. Temporal trends in annual prevalence of DKA were estimated using logistic regression analysis for each country, before and after adjustment for sex, age group and ethnic minority status. Results: During the study period, new-onset type 1 diabetes was diagnosed in 59,000 children (median age [interquartile range], 9.0 years [5.5–11.7]; male sex, 52.9%). The overall adjusted DKA prevalence was 29.9%, with the lowest prevalence in Sweden and Denmark and the highest in Luxembourg and Italy. The adjusted DKA prevalence significantly increased over time in Australia, Germany and the USA while it decreased in Italy. Preschool children, adolescents and children from ethnic minority groups were at highest risk of DKA at diabetes diagnosis in most countries. A significantly higher risk was also found for females in Denmark, Germany and Slovenia. Conclusions/interpretation: DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups.

KW - Children with diabetes

KW - Complications

KW - Diabetic ketoacidosis

KW - Diagnosis of diabetes

KW - Epidemiology

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85084313316&partnerID=8YFLogxK

U2 - 10.1007/s00125-020-05152-1

DO - 10.1007/s00125-020-05152-1

M3 - Journal article

C2 - 32382815

AN - SCOPUS:85084313316

VL - 63

SP - 1530

EP - 1541

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 8

ER -