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Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. / Scholten, Rebecca Harnung; Møller, Peter; Andersen, Zorana Jovanovic; Dehlendorff, Christian; Khan, Jibran; Brandt, Jørgen; Ketzel, Matthias; Knudsen, Lisbeth E.; Mathiesen, Line.

I: Environment International, Bind 146, 106202, 2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Scholten, RH, Møller, P, Andersen, ZJ, Dehlendorff, C, Khan, J, Brandt, J, Ketzel, M, Knudsen, LE & Mathiesen, L 2021, 'Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy', Environment International, bind 146, 106202. https://doi.org/10.1016/j.envint.2020.106202

APA

Scholten, R. H., Møller, P., Andersen, Z. J., Dehlendorff, C., Khan, J., Brandt, J., Ketzel, M., Knudsen, L. E., & Mathiesen, L. (2021). Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. Environment International, 146, [106202]. https://doi.org/10.1016/j.envint.2020.106202

CBE

Scholten RH, Møller P, Andersen ZJ, Dehlendorff C, Khan J, Brandt J, Ketzel M, Knudsen LE, Mathiesen L. 2021. Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. Environment International. 146:Article 106202. https://doi.org/10.1016/j.envint.2020.106202

MLA

Vancouver

Author

Scholten, Rebecca Harnung ; Møller, Peter ; Andersen, Zorana Jovanovic ; Dehlendorff, Christian ; Khan, Jibran ; Brandt, Jørgen ; Ketzel, Matthias ; Knudsen, Lisbeth E. ; Mathiesen, Line. / Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. I: Environment International. 2021 ; Bind 146.

Bibtex

@article{cef954351cb64470ba63c14439eae3be,
title = "Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy",
abstract = "Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to airpollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL inmaternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution andspatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4+, black carbon(BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participatingwomen for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TLwas investigated using distributed lag models. There were significant and positive associations between TL inumbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester.TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC,SO2, NH4+, CO and NO2 during the third trimester. There were similar inverse associations between TL fromumbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There wereweaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. Inconclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure toair pollution affecting fetal TL.",
author = "Scholten, {Rebecca Harnung} and Peter M{\o}ller and Andersen, {Zorana Jovanovic} and Christian Dehlendorff and Jibran Khan and J{\o}rgen Brandt and Matthias Ketzel and Knudsen, {Lisbeth E.} and Line Mathiesen",
year = "2021",
doi = "10.1016/j.envint.2020.106202",
language = "English",
volume = "146",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy

AU - Scholten, Rebecca Harnung

AU - Møller, Peter

AU - Andersen, Zorana Jovanovic

AU - Dehlendorff, Christian

AU - Khan, Jibran

AU - Brandt, Jørgen

AU - Ketzel, Matthias

AU - Knudsen, Lisbeth E.

AU - Mathiesen, Line

PY - 2021

Y1 - 2021

N2 - Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to airpollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL inmaternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution andspatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4+, black carbon(BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participatingwomen for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TLwas investigated using distributed lag models. There were significant and positive associations between TL inumbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester.TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC,SO2, NH4+, CO and NO2 during the third trimester. There were similar inverse associations between TL fromumbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There wereweaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. Inconclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure toair pollution affecting fetal TL.

AB - Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to airpollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL inmaternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution andspatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4+, black carbon(BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participatingwomen for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TLwas investigated using distributed lag models. There were significant and positive associations between TL inumbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester.TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC,SO2, NH4+, CO and NO2 during the third trimester. There were similar inverse associations between TL fromumbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There wereweaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. Inconclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure toair pollution affecting fetal TL.

U2 - 10.1016/j.envint.2020.106202

DO - 10.1016/j.envint.2020.106202

M3 - Journal article

C2 - 33120230

VL - 146

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 106202

ER -