Targeting the nuclear RNA exosome: Poly(A) binding proteins enter the stage

TY - JOUR

T1 - Targeting the nuclear RNA exosome

T2 - Poly(A) binding proteins enter the stage

AU - Meola, Nicola

AU - Jensen, Torben Heick

PY - 2017

Y1 - 2017

N2 - Centrally positioned in nuclear RNA metabolism, the exosome deals with virtually all transcript types. This 3'-5' exo- and endo-nucleolytic degradation machine is guided to its RNA targets by adaptor proteins that enable substrate recognition. Recently, the discovery of the 'Poly(A) tail exosome targeting (PAXT)' connection as an exosome adaptor to human nuclear polyadenylated transcripts has relighted the interest of poly(A) binding proteins (PABPs) in both RNA productive and destructive processes.

AB - Centrally positioned in nuclear RNA metabolism, the exosome deals with virtually all transcript types. This 3'-5' exo- and endo-nucleolytic degradation machine is guided to its RNA targets by adaptor proteins that enable substrate recognition. Recently, the discovery of the 'Poly(A) tail exosome targeting (PAXT)' connection as an exosome adaptor to human nuclear polyadenylated transcripts has relighted the interest of poly(A) binding proteins (PABPs) in both RNA productive and destructive processes.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85026914211&partnerID=8YFLogxK

U2 - 10.1080/15476286.2017.1312227

DO - 10.1080/15476286.2017.1312227

M3 - Journal article

C2 - 28421898

SN - 1547-6286

VL - 14

SP - 820

EP - 826

JO - RNA Biology

JF - RNA Biology

IS - 7

ER -