Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Target coverage and local recurrences after radiotherapy for sinonasal cancer in Denmark 2008–2015. A DAHANCA study. / Sharma, Maja B.; Jensen, Kenneth; Friborg, Jeppe et al.
I: Acta Oncologica, Bind 61, Nr. 2, 2022, s. 120-126.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Target coverage and local recurrences after radiotherapy for sinonasal cancer in Denmark 2008–2015. A DAHANCA study
AU - Sharma, Maja B.
AU - Jensen, Kenneth
AU - Friborg, Jeppe
AU - Smulders, Bob
AU - Andersen, Elo
AU - Samsøe, Eva
AU - Johansen, Jørgen
AU - Hansen, Christian R.
AU - Andersen, Maria
AU - Nielsen, Martin S.
AU - Filtenborg, Mads V.
AU - Ren, Jintao
AU - Korreman, Stine S.
AU - Overgaard, Jens
AU - Grau, Cai
N1 - Publisher Copyright: © 2022 Acta Oncologica Foundation.
PY - 2022
Y1 - 2022
N2 - Purpose: The study aimed to investigate the pattern of failure and describe compromises in the definition and coverage of the target for patients treated with curatively intended radiotherapy (RT) for sinonasal cancer (SNC). Methods and Material: Patients treated with curatively intended RT in 2008–2015 in Denmark for SNC were eligible for the retrospective cohort study. Information regarding diagnosis and treatment was retrieved from the national database of the Danish Head and Neck Cancer Group (DAHANCA). Imaging from the diagnosis of recurrences was collected, and the point of origin (PO) of the recurrent tumour was estimated. All treatment plans were collected and reviewed with the focus on target coverage, manual modifications of target volumes, and dose to organs at risk (OARs) above defined constraints. Results: A total of 184 patients were included in the analysis, and 76 (41%) relapsed. The majority of recurrences involved T-site (76%). Recurrence imaging of 39 patients was evaluated, and PO was established. Twenty-nine POs (74%) were located within the CTV, and the minimum dose to the PO was median 64.1 Gy (3.1–70.7). The criteria for target coverage (V95%) was not met in 89/184 (48%) of the CTV and 131/184 (71%) of the PTV. A total of 24% of CTVs had been manually modified to spare OARs of high-dose irradiation. No difference in target volume modifications was observed between patients who suffered recurrence and patients with lasting remission. Conclusion: The majority of relapses after radical treatment of SNC were located in the T-site (the primary tumour site). Multiple compromises with regards to target coverage and tolerance levels for OARs in the sinonasal region, as defined from RT guidelines, were taken. No common practice in this respect could be derived from the study.
AB - Purpose: The study aimed to investigate the pattern of failure and describe compromises in the definition and coverage of the target for patients treated with curatively intended radiotherapy (RT) for sinonasal cancer (SNC). Methods and Material: Patients treated with curatively intended RT in 2008–2015 in Denmark for SNC were eligible for the retrospective cohort study. Information regarding diagnosis and treatment was retrieved from the national database of the Danish Head and Neck Cancer Group (DAHANCA). Imaging from the diagnosis of recurrences was collected, and the point of origin (PO) of the recurrent tumour was estimated. All treatment plans were collected and reviewed with the focus on target coverage, manual modifications of target volumes, and dose to organs at risk (OARs) above defined constraints. Results: A total of 184 patients were included in the analysis, and 76 (41%) relapsed. The majority of recurrences involved T-site (76%). Recurrence imaging of 39 patients was evaluated, and PO was established. Twenty-nine POs (74%) were located within the CTV, and the minimum dose to the PO was median 64.1 Gy (3.1–70.7). The criteria for target coverage (V95%) was not met in 89/184 (48%) of the CTV and 131/184 (71%) of the PTV. A total of 24% of CTVs had been manually modified to spare OARs of high-dose irradiation. No difference in target volume modifications was observed between patients who suffered recurrence and patients with lasting remission. Conclusion: The majority of relapses after radical treatment of SNC were located in the T-site (the primary tumour site). Multiple compromises with regards to target coverage and tolerance levels for OARs in the sinonasal region, as defined from RT guidelines, were taken. No common practice in this respect could be derived from the study.
KW - IMRT
KW - pattern of failure
KW - recurrence
KW - Sinonasal cancer
KW - treatment planning
UR - http://www.scopus.com/inward/record.url?scp=85122258712&partnerID=8YFLogxK
U2 - 10.1080/0284186X.2021.2022199
DO - 10.1080/0284186X.2021.2022199
M3 - Journal article
C2 - 34979878
AN - SCOPUS:85122258712
VL - 61
SP - 120
EP - 126
JO - Acta Oncologica
JF - Acta Oncologica
SN - 0284-186X
IS - 2
ER -