t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma

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t(14;18) Translocation : A Predictive Blood Biomarker for Follicular Lymphoma. / Roulland, Sandrine; Kelly, Rachel S; Morgado, Ester; Sungalee, Stéphanie; Solal-Celigny, Philippe; Colombat, Philippe; Jouve, Nathalie; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Panico, Salvatore; Sacerdote, Carlotta; Quirós, José R; Gonzáles, Carlos A; Sánchez, Maria-José; Dorronsoro, Miren; Navarro, Carmen; Barricarte, Aurelio; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Canzian, Federico; Kaaks, Rudolf; Boeing, Heiner; Drogan, Dagmar; Nieters, Alexandra; Clavel-Chapelon, Françoise; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Lagiou, Pagona; Bueno-de-Mesquita, H Bas; Peeters, Petra H M; Vermeulen, Roel; Hallmans, Göran; Melin, Beatrice; Borgquist, Signe; Carlson, Joyce; Lund, Eiliv; Weiderpass, Elisabete; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J; Travis, Ruth C; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Salles, Gilles; Vineis, Paolo; Nadel, Bertrand.

I: Journal of Clinical Oncology, Bind 32, Nr. 13, 05.2014, s. 1347-55.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Roulland, S, Kelly, RS, Morgado, E, Sungalee, S, Solal-Celigny, P, Colombat, P, Jouve, N, Palli, D, Pala, V, Tumino, R, Panico, S, Sacerdote, C, Quirós, JR, Gonzáles, CA, Sánchez, M-J, Dorronsoro, M, Navarro, C, Barricarte, A, Tjønneland, A, Olsen, A, Overvad, K, Canzian, F, Kaaks, R, Boeing, H, Drogan, D, Nieters, A, Clavel-Chapelon, F, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Bueno-de-Mesquita, HB, Peeters, PHM, Vermeulen, R, Hallmans, G, Melin, B, Borgquist, S, Carlson, J, Lund, E, Weiderpass, E, Khaw, K-T, Wareham, N, Key, TJ, Travis, RC, Ferrari, P, Romieu, I, Riboli, E, Salles, G, Vineis, P & Nadel, B 2014, 't(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma', Journal of Clinical Oncology, bind 32, nr. 13, s. 1347-55. https://doi.org/10.1200/JCO.2013.52.8190

APA

Roulland, S., Kelly, R. S., Morgado, E., Sungalee, S., Solal-Celigny, P., Colombat, P., Jouve, N., Palli, D., Pala, V., Tumino, R., Panico, S., Sacerdote, C., Quirós, J. R., Gonzáles, C. A., Sánchez, M-J., Dorronsoro, M., Navarro, C., Barricarte, A., Tjønneland, A., ... Nadel, B. (2014). t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma. Journal of Clinical Oncology, 32(13), 1347-55. https://doi.org/10.1200/JCO.2013.52.8190

CBE

Roulland S, Kelly RS, Morgado E, Sungalee S, Solal-Celigny P, Colombat P, Jouve N, Palli D, Pala V, Tumino R, Panico S, Sacerdote C, Quirós JR, Gonzáles CA, Sánchez M-J, Dorronsoro M, Navarro C, Barricarte A, Tjønneland A, Olsen A, Overvad K, Canzian F, Kaaks R, Boeing H, Drogan D, Nieters A, Clavel-Chapelon F, Trichopoulou A, Trichopoulos D, Lagiou P, Bueno-de-Mesquita HB, Peeters PHM, Vermeulen R, Hallmans G, Melin B, Borgquist S, Carlson J, Lund E, Weiderpass E, Khaw K-T, Wareham N, Key TJ, Travis RC, Ferrari P, Romieu I, Riboli E, Salles G, Vineis P, Nadel B. 2014. t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma. Journal of Clinical Oncology. 32(13):1347-55. https://doi.org/10.1200/JCO.2013.52.8190

MLA

Roulland, Sandrine o.a.. "t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma". Journal of Clinical Oncology. 2014, 32(13). 1347-55. https://doi.org/10.1200/JCO.2013.52.8190

Vancouver

Roulland S, Kelly RS, Morgado E, Sungalee S, Solal-Celigny P, Colombat P o.a. t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma. Journal of Clinical Oncology. 2014 maj;32(13):1347-55. https://doi.org/10.1200/JCO.2013.52.8190

Author

Roulland, Sandrine ; Kelly, Rachel S ; Morgado, Ester ; Sungalee, Stéphanie ; Solal-Celigny, Philippe ; Colombat, Philippe ; Jouve, Nathalie ; Palli, Domenico ; Pala, Valeria ; Tumino, Rosario ; Panico, Salvatore ; Sacerdote, Carlotta ; Quirós, José R ; Gonzáles, Carlos A ; Sánchez, Maria-José ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte, Aurelio ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Canzian, Federico ; Kaaks, Rudolf ; Boeing, Heiner ; Drogan, Dagmar ; Nieters, Alexandra ; Clavel-Chapelon, Françoise ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Lagiou, Pagona ; Bueno-de-Mesquita, H Bas ; Peeters, Petra H M ; Vermeulen, Roel ; Hallmans, Göran ; Melin, Beatrice ; Borgquist, Signe ; Carlson, Joyce ; Lund, Eiliv ; Weiderpass, Elisabete ; Khaw, Kay-Tee ; Wareham, Nick ; Key, Timothy J ; Travis, Ruth C ; Ferrari, Pietro ; Romieu, Isabelle ; Riboli, Elio ; Salles, Gilles ; Vineis, Paolo ; Nadel, Bertrand. / t(14;18) Translocation : A Predictive Blood Biomarker for Follicular Lymphoma. I: Journal of Clinical Oncology. 2014 ; Bind 32, Nr. 13. s. 1347-55.

Bibtex

@article{8c16570d0a294328828b1d9f656cec0f,
title = "t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma",
abstract = "PURPOSE: The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precursors and whether their detection could be used as an early predictor for FL.PARTICIPANTS AND METHODS: Among 520,000 healthy participants enrolled onto the EPIC (European Prospective Investigation Into Cancer and Nutrition) cohort, we identified 100 who developed FL 2 to 161 months after enrollment. Prediagnostic blood from these and 218 controls were screened for t(14;18) using sensitive polymerase chain reaction-based assays. Results were subsequently validated in an independent cohort (65 case participants; 128 controls). Clonal relationships between t(14;18) cells and FL were also assessed by molecular backtracking of paired prediagnostic blood and tumor samples.RESULTS: Clonal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated that progression to FL occurred from t(14;18)-positive committed precursors. Furthermore, healthy participants at enrollment who developed FL up to 15 years later showed a markedly higher t(14;18) prevalence and frequency than controls (P < .001). Altogether, we estimated a 23-fold higher risk of subsequent FL in blood samples associated with a frequency > 10(-4) (odds ratio, 23.17; 95% CI, 9.98 to 67.31; P < .001). Remarkably, risk estimates remained high and significant up to 15 years before diagnosis.CONCLUSION: High t(14;18) frequency in blood from healthy individuals defines the first predictive biomarker for FL, effective years before diagnosis.",
author = "Sandrine Roulland and Kelly, {Rachel S} and Ester Morgado and St{\'e}phanie Sungalee and Philippe Solal-Celigny and Philippe Colombat and Nathalie Jouve and Domenico Palli and Valeria Pala and Rosario Tumino and Salvatore Panico and Carlotta Sacerdote and Quir{\'o}s, {Jos{\'e} R} and Gonz{\'a}les, {Carlos A} and Maria-Jos{\'e} S{\'a}nchez and Miren Dorronsoro and Carmen Navarro and Aurelio Barricarte and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Federico Canzian and Rudolf Kaaks and Heiner Boeing and Dagmar Drogan and Alexandra Nieters and Fran{\c c}oise Clavel-Chapelon and Antonia Trichopoulou and Dimitrios Trichopoulos and Pagona Lagiou and Bueno-de-Mesquita, {H Bas} and Peeters, {Petra H M} and Roel Vermeulen and G{\"o}ran Hallmans and Beatrice Melin and Signe Borgquist and Joyce Carlson and Eiliv Lund and Elisabete Weiderpass and Kay-Tee Khaw and Nick Wareham and Key, {Timothy J} and Travis, {Ruth C} and Pietro Ferrari and Isabelle Romieu and Elio Riboli and Gilles Salles and Paolo Vineis and Bertrand Nadel",
year = "2014",
month = may,
doi = "10.1200/JCO.2013.52.8190",
language = "English",
volume = "32",
pages = "1347--55",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "13",

}

RIS

TY - JOUR

T1 - t(14;18) Translocation

T2 - A Predictive Blood Biomarker for Follicular Lymphoma

AU - Roulland, Sandrine

AU - Kelly, Rachel S

AU - Morgado, Ester

AU - Sungalee, Stéphanie

AU - Solal-Celigny, Philippe

AU - Colombat, Philippe

AU - Jouve, Nathalie

AU - Palli, Domenico

AU - Pala, Valeria

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Quirós, José R

AU - Gonzáles, Carlos A

AU - Sánchez, Maria-José

AU - Dorronsoro, Miren

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Canzian, Federico

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Drogan, Dagmar

AU - Nieters, Alexandra

AU - Clavel-Chapelon, Françoise

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Lagiou, Pagona

AU - Bueno-de-Mesquita, H Bas

AU - Peeters, Petra H M

AU - Vermeulen, Roel

AU - Hallmans, Göran

AU - Melin, Beatrice

AU - Borgquist, Signe

AU - Carlson, Joyce

AU - Lund, Eiliv

AU - Weiderpass, Elisabete

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Key, Timothy J

AU - Travis, Ruth C

AU - Ferrari, Pietro

AU - Romieu, Isabelle

AU - Riboli, Elio

AU - Salles, Gilles

AU - Vineis, Paolo

AU - Nadel, Bertrand

PY - 2014/5

Y1 - 2014/5

N2 - PURPOSE: The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precursors and whether their detection could be used as an early predictor for FL.PARTICIPANTS AND METHODS: Among 520,000 healthy participants enrolled onto the EPIC (European Prospective Investigation Into Cancer and Nutrition) cohort, we identified 100 who developed FL 2 to 161 months after enrollment. Prediagnostic blood from these and 218 controls were screened for t(14;18) using sensitive polymerase chain reaction-based assays. Results were subsequently validated in an independent cohort (65 case participants; 128 controls). Clonal relationships between t(14;18) cells and FL were also assessed by molecular backtracking of paired prediagnostic blood and tumor samples.RESULTS: Clonal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated that progression to FL occurred from t(14;18)-positive committed precursors. Furthermore, healthy participants at enrollment who developed FL up to 15 years later showed a markedly higher t(14;18) prevalence and frequency than controls (P < .001). Altogether, we estimated a 23-fold higher risk of subsequent FL in blood samples associated with a frequency > 10(-4) (odds ratio, 23.17; 95% CI, 9.98 to 67.31; P < .001). Remarkably, risk estimates remained high and significant up to 15 years before diagnosis.CONCLUSION: High t(14;18) frequency in blood from healthy individuals defines the first predictive biomarker for FL, effective years before diagnosis.

AB - PURPOSE: The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precursors and whether their detection could be used as an early predictor for FL.PARTICIPANTS AND METHODS: Among 520,000 healthy participants enrolled onto the EPIC (European Prospective Investigation Into Cancer and Nutrition) cohort, we identified 100 who developed FL 2 to 161 months after enrollment. Prediagnostic blood from these and 218 controls were screened for t(14;18) using sensitive polymerase chain reaction-based assays. Results were subsequently validated in an independent cohort (65 case participants; 128 controls). Clonal relationships between t(14;18) cells and FL were also assessed by molecular backtracking of paired prediagnostic blood and tumor samples.RESULTS: Clonal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated that progression to FL occurred from t(14;18)-positive committed precursors. Furthermore, healthy participants at enrollment who developed FL up to 15 years later showed a markedly higher t(14;18) prevalence and frequency than controls (P < .001). Altogether, we estimated a 23-fold higher risk of subsequent FL in blood samples associated with a frequency > 10(-4) (odds ratio, 23.17; 95% CI, 9.98 to 67.31; P < .001). Remarkably, risk estimates remained high and significant up to 15 years before diagnosis.CONCLUSION: High t(14;18) frequency in blood from healthy individuals defines the first predictive biomarker for FL, effective years before diagnosis.

U2 - 10.1200/JCO.2013.52.8190

DO - 10.1200/JCO.2013.52.8190

M3 - Journal article

C2 - 24687831

VL - 32

SP - 1347

EP - 1355

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 13

ER -