Systemic circulating inflammatory burden and periodontitis in adolescents

TY - JOUR

T1 - Systemic circulating inflammatory burden and periodontitis in adolescents

AU - Ribeiro, Cecilia C.C.

AU - Carmo, Cadidja D.S.

AU - Benatti, Bruno B.

AU - Casarin, Renato V.C.

AU - Alves, C. M.C.

AU - Nascimento, Gustavo G.

AU - Moreira, A. R.O.

N1 - Funding Information: This study was funded by FAPEMA (Maranhão State Foundation for Research and Scientific and Technological Development), CNPq (National Council for Scientific and Technological Development), CAPES (Coordination for the Improvement of Higher Education Personnel)Finance Code 001, and PPSUS (Research Program for the Unified Health System/SUS – Ministry of Health). Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2021/10

Y1 - 2021/10

N2 - Objectives: To analyze the association between systemic inflammatory burden of cardiovascular disease (CVD) risk and periodontitis in adolescents, including mediating pathways triggered by their common risk factors. Materials and methods: Using a population-based sample study (n = 405) of Brazilian adolescents (17–18 years old), direct and mediation pathways triggered by “Socioeconomic Status,” “Adiposity,” Smoking, and “Blood Pressure” were modelled for the association between the “Systemic Circulating Inflammatory Burden of CVD Risk” (IL-1β, IL-6, IL-8, TNF-α) and the “Initial Periodontitis” (bleeding on probing (BoP), probing depth (PD) ≥ 4 mm, clinical attachment loss (CAL) ≥ 4 mm), both as continuous latent variables, using structural equation modeling. Sensitivity analysis was performed for the outcomes “Gingivitis” (visible plaque; BoP); “Moderate Periodontitis” (PD ≥ 5 mm and CAL ≥ 5 mm) and periodontitis (CDC-AAP case definition). Results: Higher “Systemic Circulating Inflammatory Burden of CVD Risk” was directly associated with higher “Initial Periodontitis” (standardized coefficient [SC] = 0.178, P value < 0.001). Lower “Socioeconomic Status” (SC = − 0.022, P value = 0.015) and Smoking (SC = 0.030, P value = 0.021) triggered the “Initial Periodontitis”, mediated by “Systemic Circulating Inflammatory Burden of CVD Risk”. Sensitivity analysis showed a dose-response relationship between “Systemic Circulating Inflammatory Burden of CVD Risk” and “Moderate Periodontitis” (SC = 0.323, P value = 0.021). Conclusions: “Systemic Circulating Inflammatory Burden of CVD Risk” appeared as an underlying mechanism of early periodontal breakdown in adolescents, also triggered by social vulnerability and smoking. Clinical relevance: The association between periodontitis and CVD in adulthood seems to establish much earlier in life than had been previously studied, giving impetus to preventive approaches focused on their common risk factors.

AB - Objectives: To analyze the association between systemic inflammatory burden of cardiovascular disease (CVD) risk and periodontitis in adolescents, including mediating pathways triggered by their common risk factors. Materials and methods: Using a population-based sample study (n = 405) of Brazilian adolescents (17–18 years old), direct and mediation pathways triggered by “Socioeconomic Status,” “Adiposity,” Smoking, and “Blood Pressure” were modelled for the association between the “Systemic Circulating Inflammatory Burden of CVD Risk” (IL-1β, IL-6, IL-8, TNF-α) and the “Initial Periodontitis” (bleeding on probing (BoP), probing depth (PD) ≥ 4 mm, clinical attachment loss (CAL) ≥ 4 mm), both as continuous latent variables, using structural equation modeling. Sensitivity analysis was performed for the outcomes “Gingivitis” (visible plaque; BoP); “Moderate Periodontitis” (PD ≥ 5 mm and CAL ≥ 5 mm) and periodontitis (CDC-AAP case definition). Results: Higher “Systemic Circulating Inflammatory Burden of CVD Risk” was directly associated with higher “Initial Periodontitis” (standardized coefficient [SC] = 0.178, P value < 0.001). Lower “Socioeconomic Status” (SC = − 0.022, P value = 0.015) and Smoking (SC = 0.030, P value = 0.021) triggered the “Initial Periodontitis”, mediated by “Systemic Circulating Inflammatory Burden of CVD Risk”. Sensitivity analysis showed a dose-response relationship between “Systemic Circulating Inflammatory Burden of CVD Risk” and “Moderate Periodontitis” (SC = 0.323, P value = 0.021). Conclusions: “Systemic Circulating Inflammatory Burden of CVD Risk” appeared as an underlying mechanism of early periodontal breakdown in adolescents, also triggered by social vulnerability and smoking. Clinical relevance: The association between periodontitis and CVD in adulthood seems to establish much earlier in life than had been previously studied, giving impetus to preventive approaches focused on their common risk factors.

KW - Adiposity

KW - Adolescent

KW - Inflammation mediators

KW - Periodontitis

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=85103182320&partnerID=8YFLogxK

U2 - 10.1007/s00784-021-03891-y

DO - 10.1007/s00784-021-03891-y

M3 - Journal article

C2 - 33759000

AN - SCOPUS:85103182320

SN - 1432-6981

VL - 25

SP - 5855

EP - 5865

JO - Clinical Oral Investigations

JF - Clinical Oral Investigations

IS - 10

ER -