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Synthetic chemical ligands and cognate antibodies for biorthogonal drug targeting and cell engineering

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DOI

A vast range of biomedical applications relies on the specificity of interactions between an antigen and its cognate receptor or antibody. This specificity can be highest when said antigen is a non-natural (synthetic) molecule introduced into a biological setting as a bio-orthogonal ligand. This review aims to present the development of this methodology from the early discovery of haptens a century ago to the recent clinical trials. We discuss such methodologies as antibody recruitment, artificial internalizing receptors and chemically induced dimerization, present the use of chimeric receptors and/or bispecific antibodies to achieve drug targeting and transcytosis, and illustrate how these platforms most impressively found use in the engineering of therapeutic cells such as the chimeric antigen receptor cells. This review aims to be of interest to a broad scientific audience and to spur the development of synthetic artificial ligands for biomedical applications.

OriginalsprogEngelsk
TidsskriftAdvanced Drug Delivery Reviews
Vol/bind170
Sider (fra-til)281-293
Antal sider13
ISSN0169-409X
DOI
StatusUdgivet - mar. 2021

Bibliografisk note

Funding Information:
We wish to acknowledge funding from the Lundbeck Foundation (Grant No R164-2013-15291 , to ANZ), the Independent Research Fund Denmark (DFF FNU Grant No 0135-00162B , to ANZ), the Novo Nordisk Foundation (Grant No NNF20OC0062131 , to ANZ), and the National Health and Medical Research Council Fellowship (Grant No APP1173428 , to RC).

Publisher Copyright:
© 2021 Elsevier B.V.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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