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Synthesis of Fluorosurfactants for Emulsion-Based Biological Applications

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  • Ya-Ling Chiu, Department of Biomedical Engineering, Duke University , North Carolina 27708, United States.
  • ,
  • Hon Fai Chan, Department of Biomedical Engineering, Duke University , North Carolina 27708, United States., USA
  • Kyle K L Phua, Department of Biomedical Engineering, Duke University , North Carolina 27708, United States., Department of Chemical & Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore, USA
  • Ying Zhang, Department of Biomedical Engineering, Duke University , North Carolina 27708, United States., USA
  • Sissel Juul, Department of Biomedical Engineering, Duke University , North Carolina 27708, United States.
  • ,
  • Birgitta R Knudsen
  • Kam W Leong, Department of Biomedical Engineering, Duke University , North Carolina 27708, United States., USA
  • Yi-Ping Ho, Danmark

Microemulsion represents an attractive platform for fundamental and applied biomedical research because the emulsified droplets can serve as millions of compartmentalized micrometer-sized reactors amenable to high-throughput screening or online monitoring. However, establishing stable emulsions with surfactants that are compatible with biological applications remains a significant challenge. Motivated by the lack of commercially available surfactants suitable for microemulsion-based biological assays, this study describes the facile synthesis of a biocompatible fluorosurfactant with nonionic tris(hydroxymethyl)methyl (Tris) polar head groups. We have further demonstrated compatibility of the developed surfactant with diverse emulsion-based applications, including DNA polymeric nanoparticle synthesis, enzymatic activity assay, and bacterial or mammalian cell culture, in the setup of both double- and multiphases of emulsions.

OriginalsprogEngelsk
TidsskriftACS Nano
Vol/bind8
Nummer4
Sider (fra-til)3913-3920
Antal sider8
ISSN1936-0851
DOI
StatusUdgivet - 25 mar. 2014

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