Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma

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Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma. / Khezrian, Somayeh; Khoee, Sepideh; Caceres, Marleny.

I: Journal of Biomedical Materials Research - Part A, Bind 108, Nr. 11, 2020, s. 2291-2304.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Khezrian, S, Khoee, S & Caceres, M 2020, 'Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma', Journal of Biomedical Materials Research - Part A, bind 108, nr. 11, s. 2291-2304. https://doi.org/10.1002/jbm.a.36986

APA

Khezrian, S., Khoee, S., & Caceres, M. (2020). Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma. Journal of Biomedical Materials Research - Part A, 108(11), 2291-2304. https://doi.org/10.1002/jbm.a.36986

CBE

Khezrian S, Khoee S, Caceres M. 2020. Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma. Journal of Biomedical Materials Research - Part A. 108(11):2291-2304. https://doi.org/10.1002/jbm.a.36986

MLA

Khezrian, Somayeh, Sepideh Khoee og Marleny Caceres. "Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma". Journal of Biomedical Materials Research - Part A. 2020, 108(11). 2291-2304. https://doi.org/10.1002/jbm.a.36986

Vancouver

Khezrian S, Khoee S, Caceres M. Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma. Journal of Biomedical Materials Research - Part A. 2020;108(11):2291-2304. https://doi.org/10.1002/jbm.a.36986

Author

Khezrian, Somayeh ; Khoee, Sepideh ; Caceres, Marleny. / Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma. I: Journal of Biomedical Materials Research - Part A. 2020 ; Bind 108, Nr. 11. s. 2291-2304.

Bibtex

@article{cda886d7666c4b909a6b9fbd165d19b4,
title = "Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma",
abstract = "Active targeted nanotechnology-based drug delivery systems have gained significant favor because they have the ability to decrease side effects, improve drug bioavailability, and the potency of anticancer treatment. In this study, functional amphiphilic Janus nanoparticles (JNPs), consisting of hydrophilic and hydrophobic biocompatible polymers as two distinct sides, have been prepared via a robust and simple synthesis method. The surface-active hydrophilic side of this Janus platform is functionalized with an aptamer against epithelial cell adhesion molecule (EpCAM) to deliver Doxorubicin (DOX) for the treatment of metastasis colorectal adenocarcinoma HT29 cells. The Janus morphology of the nanoparticles and their cell penetration behavior are shown in microscopic evaluations. By evaluating the prepared DOX-loaded aptamer–modified JNPs by cell-toxicity assay and confocal microscopy, it was determined that the utilization of an internalization strategy to enhance cell uptake would increase the anticancer effect of the Janus nanocarrier and improve the capacity to deliver the chemotherapeutical drug site-specifically.",
keywords = "click reaction, colorectal adenocarcinoma, EpCAM aptamer, polymeric Janus nanoparticles, targeted drug-delivery, POLYMERS, DRUG-DELIVERY, EFFICIENT ROUTE, NANOMEDICINE, APTAMER, CANCER, CELL ADHESION MOLECULE, ATRP, FABRICATION",
author = "Somayeh Khezrian and Sepideh Khoee and Marleny Caceres",
year = "2020",
doi = "10.1002/jbm.a.36986",
language = "English",
volume = "108",
pages = "2291--2304",
journal = "Journal of Biomedical Materials Research. Part A",
issn = "1549-3296",
publisher = "JohnWiley & Sons, Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Synthesis of combinatorial Janus nanoparticles based on EpCAM-PEG/PCL for targeted therapy of human colorectal adenocarcinoma

AU - Khezrian, Somayeh

AU - Khoee, Sepideh

AU - Caceres, Marleny

PY - 2020

Y1 - 2020

N2 - Active targeted nanotechnology-based drug delivery systems have gained significant favor because they have the ability to decrease side effects, improve drug bioavailability, and the potency of anticancer treatment. In this study, functional amphiphilic Janus nanoparticles (JNPs), consisting of hydrophilic and hydrophobic biocompatible polymers as two distinct sides, have been prepared via a robust and simple synthesis method. The surface-active hydrophilic side of this Janus platform is functionalized with an aptamer against epithelial cell adhesion molecule (EpCAM) to deliver Doxorubicin (DOX) for the treatment of metastasis colorectal adenocarcinoma HT29 cells. The Janus morphology of the nanoparticles and their cell penetration behavior are shown in microscopic evaluations. By evaluating the prepared DOX-loaded aptamer–modified JNPs by cell-toxicity assay and confocal microscopy, it was determined that the utilization of an internalization strategy to enhance cell uptake would increase the anticancer effect of the Janus nanocarrier and improve the capacity to deliver the chemotherapeutical drug site-specifically.

AB - Active targeted nanotechnology-based drug delivery systems have gained significant favor because they have the ability to decrease side effects, improve drug bioavailability, and the potency of anticancer treatment. In this study, functional amphiphilic Janus nanoparticles (JNPs), consisting of hydrophilic and hydrophobic biocompatible polymers as two distinct sides, have been prepared via a robust and simple synthesis method. The surface-active hydrophilic side of this Janus platform is functionalized with an aptamer against epithelial cell adhesion molecule (EpCAM) to deliver Doxorubicin (DOX) for the treatment of metastasis colorectal adenocarcinoma HT29 cells. The Janus morphology of the nanoparticles and their cell penetration behavior are shown in microscopic evaluations. By evaluating the prepared DOX-loaded aptamer–modified JNPs by cell-toxicity assay and confocal microscopy, it was determined that the utilization of an internalization strategy to enhance cell uptake would increase the anticancer effect of the Janus nanocarrier and improve the capacity to deliver the chemotherapeutical drug site-specifically.

KW - click reaction

KW - colorectal adenocarcinoma

KW - EpCAM aptamer

KW - polymeric Janus nanoparticles

KW - targeted drug-delivery

KW - POLYMERS

KW - DRUG-DELIVERY

KW - EFFICIENT ROUTE

KW - NANOMEDICINE

KW - APTAMER

KW - CANCER

KW - CELL ADHESION MOLECULE

KW - ATRP

KW - FABRICATION

UR - http://www.scopus.com/inward/record.url?scp=85086124444&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.36986

DO - 10.1002/jbm.a.36986

M3 - Journal article

C2 - 32363740

AN - SCOPUS:85086124444

VL - 108

SP - 2291

EP - 2304

JO - Journal of Biomedical Materials Research. Part A

JF - Journal of Biomedical Materials Research. Part A

SN - 1549-3296

IS - 11

ER -