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Synergistic Inhibitory Effect of Peptide-Organic Coassemblies on Amyloid Aggregation

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  • Lin Niu, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Lei Liu, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci, Jiangsu Univ, Jiangsu University, Inst Adv Mat
  • ,
  • Wenhui Xi, Fudan Univ, Fudan University, Dept Phys
  • ,
  • Qiusen Han, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Qiang Li
  • ,
  • Yue Yu, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Qunxing Huang, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Fuyang Qu, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Meng Xu, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Yibao Li, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Huiwen Du, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Rong Yang, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Jacob Cramer
  • ,
  • Kurt V. Gothelf
  • Mingdong Dong
  • Flemming Besenbacher
  • Qingdao Zeng, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Chen Wang, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci
  • ,
  • Guanghong Wei, Fudan Univ, Fudan University, Dept Phys
  • ,
  • Yanlian Yang, Natl Ctr Nanosci & Technol, Chinese Academy of Sciences, National Center for Nanoscience & Technology - China, CAS Ctr Excellence Nanosci

Inhibition of amyloid aggregation is important for developing potential therapeutic strategies of amyloidrelated diseases. Herein, we report that the inhibition effect of a pristine peptide motif (KLVFF) can be significantly improved by introducing a terminal regulatory moiety (terpyridine). The molecular-level observations by using scanning tunneling microscopy reveal stoichiometry-dependent polymorphism of the coassembly structures, which originates from the terminal interactions of peptide with organic modulator moieties and can be attributed to the secondary structures of peptides and conformations of the organic molecules. Furthermore, the polymorphism of the peptide organic coassemblies is shown to be correlated to distinctively different inhibition effects on amyloid-beta 42 (A beta 42) aggregations and cytotoxicity.

OriginalsprogEngelsk
TidsskriftA C S Nano
Vol/bind10
Nummer4
Sider (fra-til)4143-4153
Antal sider11
ISSN1936-0851
DOI
StatusUdgivet - apr. 2016

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