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Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Standard

Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. / Xu, Ruodan; Zhang, Zhongyang; Toftdal, Mette Steen et al.
I: Journal of Controlled Release, Bind 301, 2019, s. 129-139.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Xu, R, Zhang, Z, Toftdal, MS, Møller, AC, Dagnaes-Hansen, F, Dong, M, Thomsen, JS, Brüel, A & Chen, M 2019, 'Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis', Journal of Controlled Release, bind 301, s. 129-139. https://doi.org/10.1016/j.jconrel.2019.02.037

APA

Xu, R., Zhang, Z., Toftdal, M. S., Møller, A. C., Dagnaes-Hansen, F., Dong, M., Thomsen, J. S., Brüel, A., & Chen, M. (2019). Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. Journal of Controlled Release, 301, 129-139. https://doi.org/10.1016/j.jconrel.2019.02.037

CBE

Xu R, Zhang Z, Toftdal MS, Møller AC, Dagnaes-Hansen F, Dong M, Thomsen JS, Brüel A, Chen M. 2019. Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. Journal of Controlled Release. 301:129-139. https://doi.org/10.1016/j.jconrel.2019.02.037

MLA

Xu, Ruodan et al. "Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis". Journal of Controlled Release. 2019, 301. 129-139. https://doi.org/10.1016/j.jconrel.2019.02.037

Vancouver

Xu R, Zhang Z, Toftdal MS, Møller AC, Dagnaes-Hansen F, Dong M et al. Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. Journal of Controlled Release. 2019;301:129-139. doi: 10.1016/j.jconrel.2019.02.037

Author

Xu, Ruodan ; Zhang, Zhongyang ; Toftdal, Mette Steen et al. / Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. I: Journal of Controlled Release. 2019 ; Bind 301. s. 129-139.

Bibtex

@article{ee3f6ef97cb0483cbf59a23a831cc86d,
title = "Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis",
abstract = "In bone tissue engineering, electrospun fibrous scaffolds can provide excellent mechanical support, extracellular matrix mimicking components, such as 3D spacial fibrous environment for cell growth and controlled release of signaling molecules for osteogenesis. Here, a facile strategy comprising the incorporation of an osteogenic inductive peptide H1, derived from the cysteine knot (CT) domain of connective tissue growth factor (CTGF), in the core of Silk Fibroin (SF) was developed for osteogenic induction, synergistically with co-delivering hydroxyapatite (HA) from the shell of poly(l-lactic acid-co-ε-caprolactone) (PLCL). The core-shell nanofibrous structure was confirmed by transmission electron microscopy (TEM). Furthermore, the sustained released H1 has effectively promoted proliferation and osteoblastic differentiation of human induced pluripotent stem cells-derived mesenchymal stem cells (hiPS-MSCs). Moreover, after 8 weeks implantation in mice, this SF-H1/PLCL-HA composite induced bone tissue formation significantly faster than SF/PLCL as indicated by μCT. The present study is the first to demonstrate that release of short hydrophilic peptides derived from CTGF combined with HA potentiated the regenerative capacity for healing critical sized calvarial defect in vivo.",
author = "Ruodan Xu and Zhongyang Zhang and Toftdal, {Mette Steen} and M{\o}ller, {Anne Christine} and Frederik Dagnaes-Hansen and Mingdong Dong and Thomsen, {Jesper Skovhus} and Annemarie Br{\"u}el and Menglin Chen",
note = "Copyright {\textcopyright} 2019. Published by Elsevier B.V.",
year = "2019",
doi = "10.1016/j.jconrel.2019.02.037",
language = "English",
volume = "301",
pages = "129--139",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis

AU - Xu, Ruodan

AU - Zhang, Zhongyang

AU - Toftdal, Mette Steen

AU - Møller, Anne Christine

AU - Dagnaes-Hansen, Frederik

AU - Dong, Mingdong

AU - Thomsen, Jesper Skovhus

AU - Brüel, Annemarie

AU - Chen, Menglin

N1 - Copyright © 2019. Published by Elsevier B.V.

PY - 2019

Y1 - 2019

N2 - In bone tissue engineering, electrospun fibrous scaffolds can provide excellent mechanical support, extracellular matrix mimicking components, such as 3D spacial fibrous environment for cell growth and controlled release of signaling molecules for osteogenesis. Here, a facile strategy comprising the incorporation of an osteogenic inductive peptide H1, derived from the cysteine knot (CT) domain of connective tissue growth factor (CTGF), in the core of Silk Fibroin (SF) was developed for osteogenic induction, synergistically with co-delivering hydroxyapatite (HA) from the shell of poly(l-lactic acid-co-ε-caprolactone) (PLCL). The core-shell nanofibrous structure was confirmed by transmission electron microscopy (TEM). Furthermore, the sustained released H1 has effectively promoted proliferation and osteoblastic differentiation of human induced pluripotent stem cells-derived mesenchymal stem cells (hiPS-MSCs). Moreover, after 8 weeks implantation in mice, this SF-H1/PLCL-HA composite induced bone tissue formation significantly faster than SF/PLCL as indicated by μCT. The present study is the first to demonstrate that release of short hydrophilic peptides derived from CTGF combined with HA potentiated the regenerative capacity for healing critical sized calvarial defect in vivo.

AB - In bone tissue engineering, electrospun fibrous scaffolds can provide excellent mechanical support, extracellular matrix mimicking components, such as 3D spacial fibrous environment for cell growth and controlled release of signaling molecules for osteogenesis. Here, a facile strategy comprising the incorporation of an osteogenic inductive peptide H1, derived from the cysteine knot (CT) domain of connective tissue growth factor (CTGF), in the core of Silk Fibroin (SF) was developed for osteogenic induction, synergistically with co-delivering hydroxyapatite (HA) from the shell of poly(l-lactic acid-co-ε-caprolactone) (PLCL). The core-shell nanofibrous structure was confirmed by transmission electron microscopy (TEM). Furthermore, the sustained released H1 has effectively promoted proliferation and osteoblastic differentiation of human induced pluripotent stem cells-derived mesenchymal stem cells (hiPS-MSCs). Moreover, after 8 weeks implantation in mice, this SF-H1/PLCL-HA composite induced bone tissue formation significantly faster than SF/PLCL as indicated by μCT. The present study is the first to demonstrate that release of short hydrophilic peptides derived from CTGF combined with HA potentiated the regenerative capacity for healing critical sized calvarial defect in vivo.

U2 - 10.1016/j.jconrel.2019.02.037

DO - 10.1016/j.jconrel.2019.02.037

M3 - Journal article

C2 - 30880079

VL - 301

SP - 129

EP - 139

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

ER -