Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

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  • Marco Bocchio, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK; INMED, INSERM U901, 163 Avenue de Luminy, 13273 Marseille, France.
  • ,
  • Sadegh Nabavi
  • Marco Capogna

The neuronal circuits of the basolateral amygdala (BLA) are crucial for acquisition, consolidation, retrieval, and extinction of associative emotional memories. Synaptic plasticity in BLA neurons is essential for associative emotional learning and is a candidate mechanism through which subsets of BLA neurons (commonly termed "engram") are recruited during learning and reactivated during memory retrieval. In parallel, synchronous oscillations in the theta and gamma bands between the BLA and interconnected structures have been shown to occur during consolidation and retrieval of emotional memories. Understanding how these cellular and network phenomena interact is vital to decipher the roles of emotional memory formation and storage in the healthy and pathological brain. Here, we review data on synaptic plasticity, engrams, and network oscillations in the rodent BLA. We explore mechanisms through which synaptic plasticity, engrams, and long-range synchrony might be interconnected.

OriginalsprogEngelsk
TidsskriftNeuron
Vol/bind94
Nummer4
Sider (fra-til)731-743
Antal sider13
ISSN0896-6273
DOI
StatusUdgivet - 17 maj 2017

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