Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study

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Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study. / Jensen, Pernille T.; Schnack, Tine H.; Frøding, Ligita P.; Bjørn, Signe F.; Lajer, Henrik; Markauskas, Algirdas; Jochumsen, Kirsten M.; Fuglsang, Katrine; Dinesen, Jacob; Søgaard, Charlotte H.; Søgaard-Andersen, Erik; Jensen, Marianne M.; Knudsen, Aage; Øster, Laura H.; Høgdall, Claus.

I: European Journal of Cancer, Bind 128, 2020, s. 47-56.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Jensen, PT, Schnack, TH, Frøding, LP, Bjørn, SF, Lajer, H, Markauskas, A, Jochumsen, KM, Fuglsang, K, Dinesen, J, Søgaard, CH, Søgaard-Andersen, E, Jensen, MM, Knudsen, A, Øster, LH & Høgdall, C 2020, 'Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study', European Journal of Cancer, bind 128, s. 47-56. https://doi.org/10.1016/j.ejca.2019.12.020

APA

Jensen, P. T., Schnack, T. H., Frøding, L. P., Bjørn, S. F., Lajer, H., Markauskas, A., Jochumsen, K. M., Fuglsang, K., Dinesen, J., Søgaard, C. H., Søgaard-Andersen, E., Jensen, M. M., Knudsen, A., Øster, L. H., & Høgdall, C. (2020). Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study. European Journal of Cancer, 128, 47-56. https://doi.org/10.1016/j.ejca.2019.12.020

CBE

Jensen PT, Schnack TH, Frøding LP, Bjørn SF, Lajer H, Markauskas A, Jochumsen KM, Fuglsang K, Dinesen J, Søgaard CH, Søgaard-Andersen E, Jensen MM, Knudsen A, Øster LH, Høgdall C. 2020. Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study. European Journal of Cancer. 128:47-56. https://doi.org/10.1016/j.ejca.2019.12.020

MLA

Vancouver

Author

Jensen, Pernille T. ; Schnack, Tine H. ; Frøding, Ligita P. ; Bjørn, Signe F. ; Lajer, Henrik ; Markauskas, Algirdas ; Jochumsen, Kirsten M. ; Fuglsang, Katrine ; Dinesen, Jacob ; Søgaard, Charlotte H. ; Søgaard-Andersen, Erik ; Jensen, Marianne M. ; Knudsen, Aage ; Øster, Laura H. ; Høgdall, Claus. / Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study. I: European Journal of Cancer. 2020 ; Bind 128. s. 47-56.

Bibtex

@article{9f884c2d7fa3492cbb1ed5fab5d486da,
title = "Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study",
abstract = "Aim: Lately, the safety of minimally invasive surgery (MIS) in the treatment of cervical cancer (CC) has been questioned. This study aimed to evaluate the risk of recurrence and survival after a nationwide adoption of robotic MIS for the treatment of early-stage CC in Denmark. Methods: Population-based data on all Danish women with early-stage CC, who underwent radical hysterectomy January 1st 2005–June 30th 2017 were retrieved from the Danish Gynecologic Cancer Database and enriched with follow-up data on recurrence, death and cause of death. The cohort was divided into two groups according to the year of robotic MIS introduction at each cancer centre. Chi-squared or Fischer test, the Kaplan Meier method and multivariate Cox regression were used for comparison between groups. Results: One thousand one hundred twenty-five patients with CC were included; 530 underwent surgery before (group 1) and 595 underwent surgery after (group 2) the introduction of robotic MIS. The 5-year rate of recurrence was low: 8.2% and 6.3% (p = 0.55) in group 1 and 2, respectively. In adjusted analyses, this corresponded to a five-year disease-free survival, hazard ratio (HR) 1.23 [95% confidence interval (CI) 0.79-1.93]. No difference in site of recurrence (P = 0.19) was observed. The cumulative cancer-specific survival was 94.1% and 95.9% (P = 0.10) in group 1 and 2, respectively, corresponding to a HR 0.60 [95% CI 0.32–1.11] in adjusted analyses. Conclusion: In this population-based cohort study, the Danish nationwide adoption of robotic MIS for early-stage CC was not associated with increased risk of recurrence or reduction in survival outcomes.",
keywords = "Cancer recurrence, Cancer-specific survival, Cervical cancer, Disease-free survival, Minimally invasive surgery, Overall survival, Population-based study, Radical hysterectomy, Robotic surgery",
author = "Jensen, {Pernille T.} and Schnack, {Tine H.} and Fr{\o}ding, {Ligita P.} and Bj{\o}rn, {Signe F.} and Henrik Lajer and Algirdas Markauskas and Jochumsen, {Kirsten M.} and Katrine Fuglsang and Jacob Dinesen and S{\o}gaard, {Charlotte H.} and Erik S{\o}gaard-Andersen and Jensen, {Marianne M.} and Aage Knudsen and {\O}ster, {Laura H.} and Claus H{\o}gdall",
year = "2020",
doi = "10.1016/j.ejca.2019.12.020",
language = "English",
volume = "128",
pages = "47--56",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study

AU - Jensen, Pernille T.

AU - Schnack, Tine H.

AU - Frøding, Ligita P.

AU - Bjørn, Signe F.

AU - Lajer, Henrik

AU - Markauskas, Algirdas

AU - Jochumsen, Kirsten M.

AU - Fuglsang, Katrine

AU - Dinesen, Jacob

AU - Søgaard, Charlotte H.

AU - Søgaard-Andersen, Erik

AU - Jensen, Marianne M.

AU - Knudsen, Aage

AU - Øster, Laura H.

AU - Høgdall, Claus

PY - 2020

Y1 - 2020

N2 - Aim: Lately, the safety of minimally invasive surgery (MIS) in the treatment of cervical cancer (CC) has been questioned. This study aimed to evaluate the risk of recurrence and survival after a nationwide adoption of robotic MIS for the treatment of early-stage CC in Denmark. Methods: Population-based data on all Danish women with early-stage CC, who underwent radical hysterectomy January 1st 2005–June 30th 2017 were retrieved from the Danish Gynecologic Cancer Database and enriched with follow-up data on recurrence, death and cause of death. The cohort was divided into two groups according to the year of robotic MIS introduction at each cancer centre. Chi-squared or Fischer test, the Kaplan Meier method and multivariate Cox regression were used for comparison between groups. Results: One thousand one hundred twenty-five patients with CC were included; 530 underwent surgery before (group 1) and 595 underwent surgery after (group 2) the introduction of robotic MIS. The 5-year rate of recurrence was low: 8.2% and 6.3% (p = 0.55) in group 1 and 2, respectively. In adjusted analyses, this corresponded to a five-year disease-free survival, hazard ratio (HR) 1.23 [95% confidence interval (CI) 0.79-1.93]. No difference in site of recurrence (P = 0.19) was observed. The cumulative cancer-specific survival was 94.1% and 95.9% (P = 0.10) in group 1 and 2, respectively, corresponding to a HR 0.60 [95% CI 0.32–1.11] in adjusted analyses. Conclusion: In this population-based cohort study, the Danish nationwide adoption of robotic MIS for early-stage CC was not associated with increased risk of recurrence or reduction in survival outcomes.

AB - Aim: Lately, the safety of minimally invasive surgery (MIS) in the treatment of cervical cancer (CC) has been questioned. This study aimed to evaluate the risk of recurrence and survival after a nationwide adoption of robotic MIS for the treatment of early-stage CC in Denmark. Methods: Population-based data on all Danish women with early-stage CC, who underwent radical hysterectomy January 1st 2005–June 30th 2017 were retrieved from the Danish Gynecologic Cancer Database and enriched with follow-up data on recurrence, death and cause of death. The cohort was divided into two groups according to the year of robotic MIS introduction at each cancer centre. Chi-squared or Fischer test, the Kaplan Meier method and multivariate Cox regression were used for comparison between groups. Results: One thousand one hundred twenty-five patients with CC were included; 530 underwent surgery before (group 1) and 595 underwent surgery after (group 2) the introduction of robotic MIS. The 5-year rate of recurrence was low: 8.2% and 6.3% (p = 0.55) in group 1 and 2, respectively. In adjusted analyses, this corresponded to a five-year disease-free survival, hazard ratio (HR) 1.23 [95% confidence interval (CI) 0.79-1.93]. No difference in site of recurrence (P = 0.19) was observed. The cumulative cancer-specific survival was 94.1% and 95.9% (P = 0.10) in group 1 and 2, respectively, corresponding to a HR 0.60 [95% CI 0.32–1.11] in adjusted analyses. Conclusion: In this population-based cohort study, the Danish nationwide adoption of robotic MIS for early-stage CC was not associated with increased risk of recurrence or reduction in survival outcomes.

KW - Cancer recurrence

KW - Cancer-specific survival

KW - Cervical cancer

KW - Disease-free survival

KW - Minimally invasive surgery

KW - Overall survival

KW - Population-based study

KW - Radical hysterectomy

KW - Robotic surgery

UR - http://www.scopus.com/inward/record.url?scp=85079122269&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2019.12.020

DO - 10.1016/j.ejca.2019.12.020

M3 - Journal article

C2 - 32109850

AN - SCOPUS:85079122269

VL - 128

SP - 47

EP - 56

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

ER -