TY - JOUR
T1 - Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation
AU - Su, Yingchun
AU - Zhang, Yuge
AU - Chen, Yang
AU - Majidi, Sara Seidelin
AU - Dong, Mingdong
AU - Chen, Menglin
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/2
Y1 - 2024/2
N2 - As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.
AB - As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.
KW - Lumbar vertebra-like scaffold
KW - Melt electrowriting
KW - Osteogenic differentiation
KW - Polycaprolactone
KW - Surface recrystallization
UR - http://www.scopus.com/inward/record.url?scp=85183930252&partnerID=8YFLogxK
U2 - 10.1016/j.mtphys.2024.101344
DO - 10.1016/j.mtphys.2024.101344
M3 - Journal article
AN - SCOPUS:85183930252
SN - 2542-5293
VL - 41
JO - Materials Today Physics
JF - Materials Today Physics
M1 - 101344
ER -