Substitutions between potatoes and other vegetables and risk of ischemic stroke

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Mette Damborg Hansen
  • ,
  • Anne Mette Lund Würtz
  • Camilla Plambeck Hansen, The Danish Clinical Quality Program (RKKP), National Clinical Registries, Aarhus, Denmark.
  • ,
  • Anne Tjønneland, Københavns Universitet, The Danish Cancer Society Research Center, Danmark
  • Eric Bruce Rimm, Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA., USA
  • Søren Paaske Johnsen, Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University and Aalborg University Hospital, Aalborg, Denmark.
  • ,
  • Erik Berg Schmidt, Aalborg Universitet
  • ,
  • Kim Overvad
  • Marianne Uhre Jakobsen, Division for Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kemitorvet 2, 2800, Kgs. Lyngby, Denmark.

PURPOSE: Intake of vegetables has been associated with a lower risk of ischemic stroke in observational studies controlling for total energy intake. However, adjustment for energy intake introduces a substitution aspect, which affects the interpretation of the results. We investigated replacement of potatoes with other vegetables, substitutions between vegetable subgroups, and risk of ischemic stroke and ischemic stroke subtypes.

METHODS: The Danish Diet, Cancer and Health cohort included 57,053 participants aged 50-64 years at recruitment in 1993-1997. Diet was assessed from a validated 192-item semi-quantitative food frequency questionnaire. We calculated hazard ratios (HR) with 95% confidence intervals (CI) for the incidence of ischemic stroke using Cox proportional hazard regression.

RESULTS: During 13.5 years of follow-up, 1879 cases of ischemic stroke were identified including 319 cases of large-artery atherosclerosis and 844 cases of small-vessel occlusion. The adjusted HR for total ischemic stroke associated with food substitutions of equal amounts (500 g/week) was 0.86 (95% CI 0.76, 0.97) for replacement of potatoes with fruiting vegetables and 0.92 (95% CI 0.84, 1.02) for replacement of potatoes with other root vegetables. The HR for replacing potatoes with the sum of other vegetables was 0.95 (95% CI 0.90, 1.00). Substitution of cabbage for either potatoes, fruiting vegetables or other root vegetables was associated with a statistically non-significant higher risk of ischemic stroke. The patterns of associations were similar for ischemic stroke subtypes and for equivalent substitutions using isocaloric amounts.

CONCLUSION: Replacing potatoes with fruiting vegetables was associated with a lower risk of ischemic stroke.

TidsskriftEuropean Journal of Nutrition
Sider (fra-til)229–237
Antal sider9
StatusUdgivet - feb. 2021

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