Studying mutation rate evolution in primates-a need for systematic comparison of computational pipelines

Lucie A. Bergeron*, Søren Besenbacher, Mikkel H. Schierup, Guojie Zhang*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisKommentar/debat/letter to the editorForskningpeer review

1 Citationer (Scopus)

Abstract

The lack of consensus methods to estimate germline mutation rates from pedigrees has led to substantial differences in computational pipelines in the published literature. Here, we answer Susanne Pfeifer's opinion piece discussing the pipeline choices of our recent article estimating the germline mutation rate of rhesus macaques (Macaca mulatta). We acknowledge the differences between the method that we applied and the one preferred by Pfeifer. Yet, we advocate for full transparency and justification of choices as long as rigorous comparison of pipelines remains absent because it is the only way to conclude on best practices for the field.

OriginalsprogEngelsk
Artikelnummergiab072
TidsskriftGigaScience
Vol/bind10
Nummer10
ISSN2047-217X
DOI
StatusUdgivet - okt. 2021

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