Structures of benzo(a)pyrene-nucleic acid adducts formed in human and bovine bronchial explants

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  • A.M. Jeffrey, USA
  • I.B. Weinstein, USA
  • K.W. Jenette, USA
  • K. Grzeskowiak, USA
  • K. Nakanishi, USA
  • R.G. Harvey, USA
  • Herman Autrup
  • C. Harris, USA
  • Afdeling for Miljø- og Arbejdsmedicin
PUBLICATION by Sims et al. of evidence that the 7,8-dihydrodiol-9,10-oxide of benzo(a)pyrene (BP) is a metabolic intermediate in the covalent binding of this ubiquitous polycyclic aromatic hydrocarbon to DNA in hamster embryo cells1 was followed by many related publications2. Grover et al. 3 also obtained evidence that the same derivative is involved in the binding of BP to the DNA of human bronchial explants, although details of the specific isomer involved and of the structure of the adduct were not reported. We describe here studies on RNA and DNA adducts formed by human bronchial explants and provide evidence that the structures of the major adducts are similar to those formed in the analogous bovine system.
Sider (fra-til)348-350
Antal sider3
StatusUdgivet - 22 sep. 1977

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