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Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Standard

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. / Andersen, Christian Brix Folsted; Ballut, Lionel; Johansen, Jesper Sanderhoff et al.

I: Science, Bind 313, 2006, s. 1968-1972.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Andersen, CBF, Ballut, L, Johansen, JS, Chamieh, H, Nielsen, KH, Oliveira, C, Pedersen, JS, Seraphin, B, LeHir, H & Andersen, GR 2006, 'Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA', Science, bind 313, s. 1968-1972.

APA

Andersen, C. B. F., Ballut, L., Johansen, J. S., Chamieh, H., Nielsen, K. H., Oliveira, C., Pedersen, J. S., Seraphin, B., LeHir, H., & Andersen, G. R. (2006). Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science, 313, 1968-1972.

CBE

Andersen CBF, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira C, Pedersen JS, Seraphin B, LeHir H, Andersen GR. 2006. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science. 313:1968-1972.

MLA

Andersen, Christian Brix Folsted et al. "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA". Science. 2006, 313. 1968-1972.

Vancouver

Andersen CBF, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira C et al. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science. 2006;313:1968-1972.

Author

Andersen, Christian Brix Folsted ; Ballut, Lionel ; Johansen, Jesper Sanderhoff et al. / Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. I: Science. 2006 ; Bind 313. s. 1968-1972.

Bibtex

@article{fb59ca00c65f11dbbee902004c4f4f50,
title = "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA",
abstract = "In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.",
keywords = "splicing, mRNA metabolism, DEAD-box",
author = "Andersen, {Christian Brix Folsted} and Lionel Ballut and Johansen, {Jesper Sanderhoff} and H. Chamieh and Nielsen, {Klaus Hvid} and Cristiano Oliveira and Pedersen, {Jan Skov} and B. Seraphin and H. LeHir and Andersen, {Gregers Rom}",
year = "2006",
language = "English",
volume = "313",
pages = "1968--1972",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

}

RIS

TY - JOUR

T1 - Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

AU - Andersen, Christian Brix Folsted

AU - Ballut, Lionel

AU - Johansen, Jesper Sanderhoff

AU - Chamieh, H.

AU - Nielsen, Klaus Hvid

AU - Oliveira, Cristiano

AU - Pedersen, Jan Skov

AU - Seraphin, B.

AU - LeHir, H.

AU - Andersen, Gregers Rom

PY - 2006

Y1 - 2006

N2 - In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.

AB - In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.

KW - splicing

KW - mRNA metabolism

KW - DEAD-box

M3 - Journal article

VL - 313

SP - 1968

EP - 1972

JO - Science

JF - Science

SN - 0036-8075

ER -