Structure, function and nutritional potential of milk osteopontin

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Structure, function and nutritional potential of milk osteopontin. / Christensen, Brian Søndergaard; Sørensen, Esben Skipper.

I: International Dairy Journal, Bind 57, 2016, s. 1-6.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{9fa9b67174fe4891835a45643b9bc9eb,
title = "Structure, function and nutritional potential of milk osteopontin",
abstract = "Osteopontin (OPN) is a multifunctional protein present in most tissues and body fluids, with the highest concentrations found in milk. Processes for isolation of OPN from bovine milk for use in infant formula have been developed and studies have investigated the effects of oral administration of milk OPN. At the same time, plasma OPN levels have been shown to be elevated in some types of cancer, and OPN has been suggested as a potential diagnostic marker for cancer. OPN exists in several different isoforms in vivo, of which presumably only a minority is directly or indirectly implicated in cancer related events. In this article, we review the differences between milk-derived OPN and OPN derived from transformed cells and compare the structure of OPN from human and bovine milk. Furthermore, current knowledge about the function of OPN in milk and recent findings about the effect of orally presented OPN is discussed.",
author = "Christensen, {Brian S{\o}ndergaard} and S{\o}rensen, {Esben Skipper}",
year = "2016",
language = "English",
volume = "57",
pages = "1--6",
journal = "International Dairy Journal",
issn = "0958-6946",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Structure, function and nutritional potential of milk osteopontin

AU - Christensen, Brian Søndergaard

AU - Sørensen, Esben Skipper

PY - 2016

Y1 - 2016

N2 - Osteopontin (OPN) is a multifunctional protein present in most tissues and body fluids, with the highest concentrations found in milk. Processes for isolation of OPN from bovine milk for use in infant formula have been developed and studies have investigated the effects of oral administration of milk OPN. At the same time, plasma OPN levels have been shown to be elevated in some types of cancer, and OPN has been suggested as a potential diagnostic marker for cancer. OPN exists in several different isoforms in vivo, of which presumably only a minority is directly or indirectly implicated in cancer related events. In this article, we review the differences between milk-derived OPN and OPN derived from transformed cells and compare the structure of OPN from human and bovine milk. Furthermore, current knowledge about the function of OPN in milk and recent findings about the effect of orally presented OPN is discussed.

AB - Osteopontin (OPN) is a multifunctional protein present in most tissues and body fluids, with the highest concentrations found in milk. Processes for isolation of OPN from bovine milk for use in infant formula have been developed and studies have investigated the effects of oral administration of milk OPN. At the same time, plasma OPN levels have been shown to be elevated in some types of cancer, and OPN has been suggested as a potential diagnostic marker for cancer. OPN exists in several different isoforms in vivo, of which presumably only a minority is directly or indirectly implicated in cancer related events. In this article, we review the differences between milk-derived OPN and OPN derived from transformed cells and compare the structure of OPN from human and bovine milk. Furthermore, current knowledge about the function of OPN in milk and recent findings about the effect of orally presented OPN is discussed.

M3 - Journal article

VL - 57

SP - 1

EP - 6

JO - International Dairy Journal

JF - International Dairy Journal

SN - 0958-6946

ER -